Details of the Target

General Information of Target

Target ID LDTP13480
Target Name Zinc finger protein Helios (IKZF2)
Gene Name IKZF2
Gene ID 22807
Synonyms
HELIOS; ZNFN1A2; Zinc finger protein Helios; Ikaros family zinc finger protein 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPEEDAGGEALGGSFWEAGNYRRTVQRVEDGHRLCGDLVSCFQERARIEKAYAQQLADW
ARKWRGTVEKGPQYGTLEKAWHAFFTAAERLSALHLEVREKLQGQDSERVRAWQRGAFHR
PVLGGFRESRAAEDGFRKAQKPWLKRLKEVEASKKSYHAARKDEKTAQTRESHAKADSAV
SQEQLRKLQERVERCAKEAEKTKAQYEQTLAELHRYTPRYMEDMEQAFETCQAAERQRLL
FFKDMLLTLHQHLDLSSSEKFHELHRDLHQGIEAASDEEDLRWWRSTHGPGMAMNWPQFE
EWSLDTQRTISRKEKGGRSPDEVTLTSIVPTRDGTAPPPQSPGSPGTGQDEEWSDEESPR
KAATGVRVRALYDYAGQEADELSFRAGEELLKMSEEDEQGWCQGQLQSGRIGLYPANYVE
CVGA
Target Type
Clinical trial
Target Bioclass
Transcription factor
Family
Ikaros C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function Associates with Ikaros at centromeric heterochromatin.
TTD ID
T81569
Uniprot ID
Q9UKS7
DrugMap ID
TTKT5NV
Ensemble ID
ENST00000374319.8
HGNC ID
HGNC:13177

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.R217S .
HDMYZ SNV: p.D406V .
KYSE510 SNV: p.E4K .
MFE296 SNV: p.P341S .
NCIH2122 Substitution: p.S433I .
SNU449 SNV: p.P139T .
ZR751 SNV: p.Q144K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C404(8.77)  LDD2157  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
C-terminal-binding protein 2 (CTBP2) D-isomer specific 2-hydroxyacid dehydrogenase family P56545
LON peptidase N-terminal domain and RING finger protein 1 (LONRF1) . Q17RB8
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Aquaporin-1 (AQP1) MIP/aquaporin (TC 1.A.8) family P29972

The Drug(s) Related To This Target

Phase 1
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Dky709 Small molecular drug DG9LF8

References

1 From chemoproteomic-detected amino acids to genomic coordinates: insights into precise multi-omic data integration. Mol Syst Biol. 2021 Feb;17(2):e9840. doi: 10.15252/msb.20209840.
Mass spectrometry data entry: PXD022151