Details of the Target

General Information of Target

Target ID LDTP13476
Target Name Disintegrin and metalloproteinase domain-containing protein 28 (ADAM28)
Gene Name ADAM28
Gene ID 10863
Synonyms
ADAM23; MDCL; Disintegrin and metalloproteinase domain-containing protein 28; ADAM 28; EC 3.4.24.-; Epididymal metalloproteinase-like, disintegrin-like, and cysteine-rich protein II; eMDC II; Metalloproteinase-like, disintegrin-like, and cysteine-rich protein L; MDC-L
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MALTPESPSSFPGLAATGSSVPEPPGGPNATLNSSWASPTEPSSLEDLVATGTIGTLLSA
MGVVGVVGNAYTLVVTCRSLRAVASMYVYVVNLALADLLYLLSIPFIVATYVTKEWHFGD
VGCRVLFGLDFLTMHASIFTLTVMSSERYAAVLRPLDTVQRPKGYRKLLALGTWLLALLL
TLPVMLAMRLVRRGPKSLCLPAWGPRAHRAYLTLLFATSIAGPGLLIGLLYARLARAYRR
SQRASFKRARRPGARALRLVLGIVLLFWACFLPFWLWQLLAQYHQAPLAPRTARIVNYLT
TCLTYGNSCANPFLYTLLTRNYRDHLRGRVRGPGSGGGRGPVPSLQPRARFQRCSGRSLS
SCSPQPTDSLVLAPAAPARPAPEGPRAPA
Target Bioclass
Enzyme
Subcellular location
Secreted; Cell membrane
Function
May play a role in the adhesive and proteolytic events that occur during lymphocyte emigration or may function in ectodomain shedding of lymphocyte surface target proteins, such as FASL and CD40L. May be involved in sperm maturation.
Uniprot ID
Q9UKQ2
Ensemble ID
ENST00000265769.9
HGNC ID
HGNC:206

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
COLO679 SNV: p.P357S .
HT115 SNV: p.E274D; p.A298T .
HT1197 SNV: p.M234T .
IGR1 SNV: p.Q515Ter .
IGR37 SNV: p.D422N .
IGR39 SNV: p.D422N .
IPC298 SNV: p.E340K .
KURAMOCHI SNV: p.C124F .
MFE319 Deletion: p.Y88del
Insertion: p.N75KfsTer54		 .
MIAPACA2 SNV: p.D118N .
MOLT4 SNV: p.Q446Ter .
NCIH1155 SNV: p.A302T .
NUGC3 SNV: p.H178D .
SKMEL30 SNV: p.G650R .
SNGM SNV: p.P23H .
TE11 SNV: p.Y87H; p.G502D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C585(1.51)  LDD3368  [1]
BTD
 Probe Info  		C465(2.76)  LDD2136  [2]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [3]
IPM
 Probe Info  		N.A.  LDD0147  [4]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 CC-SW-1 C585(2.36)  LDD2299  [1]
 LDCM0023  KB03 CC-SW-1 C585(1.56)  LDD2716  [1]
 LDCM0024  KB05 OAW-28 C585(1.51)  LDD3368  [1]
 LDCM0543  Nucleophilic fragment 38 MDA-MB-231 C465(2.76)  LDD2136  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Urokinase-type plasminogen activator (PLAU) Peptidase S1 family P00749

The Drug(s) Related To This Target

Approved
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Pidolic Acid Small molecular drug DB03088
Investigative
Click To Hide/Show 6 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Batimastat Small molecular drug DB03880
Ilomastat Small molecular drug DB02255
(2r3r)-n^1^-[(1s)-22-dimethyl-1-(Methylcarbamoyl)Propyl]-n^4^-hydroxy-2-(2-methylpropyl)-3-{[(13-thiazol-2-ylcarbonyl)Amino]Methyl}Butanediamide . DB08733
2-(Thiomethylene)-4-methylpentanoic Acid . DB02996
Furoyl-leucine . DB02215
N-[(Furan-2-yl)Carbonyl]-(S)-leucyl-(R)-[1-amino-2(1h-indol-3-yl)Ethyl]-phosphonic Acid . DB02046

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
3 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
4 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255