Details of the Target

General Information of Target

Target ID LDTP13470
Target Name Unconventional myosin-XV (MYO15A)
Gene Name MYO15A
Gene ID 51168
Synonyms
MYO15; Unconventional myosin-XV; Unconventional myosin-15
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MHHRMNEMNLSPVGMEQLTSSSVSNALPVSGSHLGLAASPTHSAIPAPGLPVAIPNLGPS
LSSLPSALSLMLPMGIGDRGVMCGLPERNYTLPPPPYPHLESSYFRTILPGILSYLADRP
PPQYIHPNSINVDGNTALSITNNPSALDPYQSNGNVGLEPGIVSIDSRSVNTHGAQSLHP
SDGHEVALDTAITMENVSRVTSPISTDGMAEELTMDGVAGEHSQIPNGSRSHEPLSVDSV
SNNLAADAVGHGGVIPMHGNGLELPVVMETDHIASRVNGMSDSALSDSIHTVAMSTNSVS
VALSTSHNLASLESVSLHEVGLSLEPVAVSSITQEVAMGTGHVDVSSDSLSFVSPSLQME
DSNSNKENMATLFTIWCTLCDRAYPSDCPEHGPVTFVPDTPIESRARLSLPKQLVLRQSI
VGAEVGVWTGETIPVRTCFGPLIGQQSHSMEVAEWTDKAVNHIWKIYHNGVLEFCIITTD
ENECNWMMFVRKARNREEQNLVAYPHDGKIFFCTSQDIPPENELLFYYSRDYAQQIGVPE
HPDVHLCNCGKECNSYTEFKAHLTSHIHNHLPTQGHSGSHGPSHSKERKWKCSMCPQAFI
SPSKLHVHFMGHMGMKPHKCDFCSKAFSDPSNLRTHLKIHTGQKNYRCTLCDKSFTQKAH
LESHMVIHTGEKNLKCDYCDKLFMRRQDLKQHVLIHTQERQIKCPKCDKLFLRTNHLKKH
LNSHEGKRDYVCEKCTKAYLTKYHLTRHLKTCKGPTSSSSAPEEEEEDDSEEEDLADSVG
TEDCRINSAVYSADESLSAHK
Target Bioclass
Enzyme
Family
TRAFAC class myosin-kinesin ATPase superfamily, Myosin family
Subcellular location
Cell projection, stereocilium
Function
Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Required for the arrangement of stereocilia in mature hair bundles.
Uniprot ID
Q9UKN7
Ensemble ID
ENST00000418233.7
HGNC ID
HGNC:7594
ChEMBL ID
CHEMBL4295979

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A172 Deletion: p.T2205PfsTer48 .
CCK81 SNV: p.Y274N .
COLO829 SNV: p.L3152F .
DAOY SNV: p.K140M .
DOTC24510 Deletion: p.G1382TfsTer47 .
EFO21 Deletion: p.L1848_H1853del .
HCT15 SNV: p.W2689C; p.R2939C .
HEC1 SNV: p.R41C .
HEC1B SNV: p.R41C; p.R938H .
HGC27 SNV: p.E2361K .
HKGZCC SNV: p.V722M .
HSC4 SNV: p.H2706Q .
HT115 SNV: p.S3463L .
IM95 Deletion: p.E396RfsTer48
SNV: p.R858Q		 .
Ishikawa (Heraklio) 02 ER SNV: p.E3510A .
JURKAT Deletion: p.W943GfsTer43
SNV: p.A2908T		 .
KELLY SNV: p.P2237Q; p.H2239N .
KMRC1 SNV: p.G550D .
KNS81FD SNV: p.H2568Q .
KYSE150 SNV: p.W719L .
KYSE180 SNV: p.T33M .
LNCaP clone FGC SNV: p.Q777K .
LS180 SNV: p.E3002G .
MCC13 SNV: p.N541S; p.G2781D; p.D3130N .
MCC26 SNV: p.G321E .
MDAMB157 SNV: p.Y281S .
MDAMB231 SNV: p.S2156R .
MDST8 SNV: p.R781G .
MELJUSO SNV: p.A2626S
Substitution: p.P371F		 .
MEWO SNV: p.E152K; p.P355L; p.R781K; p.W2213Ter; p.P3248L .
MFE319 SNV: p.P910S; p.K1530N; p.L2919P .
MOLT4 SNV: p.K1048E; p.R3295C .
NCIH358 SNV: p.G17W .
NCIH661 SNV: p.A351S .
OVISE SNV: p.P421T .
P31FUJ SNV: p.P213Q .
PANC0403 SNV: p.A2529D .
REH SNV: p.A2369T .
RKO SNV: p.A548T; p.L1179M .
RL952 SNV: p.F3420I .
SKMEL30 SNV: p.F964L .
SNGM SNV: p.V2940M .
SNU1 SNV: p.R742Q .
SUPT1 Deletion: p.F1371LfsTer13 .
SW1271 SNV: p.E382Ter; p.T2450I .
SW1783 SNV: p.P319L .
SW756 SNV: p.S796L .
TOV21G SNV: p.S783Ter .

Probe(s) Labeling This Target

PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-2
 Probe Info  		N.A.  LDD0138  [1]

References

1 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.