Details of the Target

General Information of Target

Target ID LDTP13396
Target Name F-box/LRR-repeat protein 7 (FBXL7)
Gene Name FBXL7
Gene ID 23194
Synonyms
FBL6; FBL7; KIAA0840; F-box/LRR-repeat protein 7; F-box and leucine-rich repeat protein 7; F-box protein FBL6/FBL7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASVVVKTIWQSKEIHEAGDTPTGVESCSQLVPEAPRRVTSRAKGIPKKKKAVSFHGVEP
QMSHQPMHWCLNLKRSSACTNVSLLNLAAMEPTDSTGTDSTVEDLSGQLTLAGPPASPTL
PWDPDDADITEILSGVNSGLVRAKDSITSLKEKTNRVNQHVQSLQSECSVLSENLERRRQ
EAEELEGYCIQLKENCWKVTRSVEDAEIKTNVLKQNSALLEEKLRYLQQQLQDETPRRQE
AELQEPEEKQEPEEKQEPEEKQKPEAGLSWNSLGPAATSQGCPGPPGSPDKPSRPHGLVP
AGWGMGPRAGEGPYVSEQELQKLFTGIEELRREVSSLTARWHQEEGAVQEALRLLGGLGG
RVDGFLGQWERAQREQAQTARDLQELRGRADELCTMVERSAVSVASLRSELEGLGPLKPI
LEEFGRQFQNSRRGPDLSMNLDRSHQGNCARCASQGSQLSTESLQQLLDRALTSLVDEVK
QRGLTPACPSCQRLHKKILELERQALAKHVRAEALSSTLRLAQDEALRAKNLLLTDKMKP
EEKMATLDHLHLKMCSLHDHLSNLPLEGSTGTMGGGSSAGTPPKQGGSAPEQ
Target Bioclass
Other
Family
FBXL7 family
Subcellular location
Cytoplasm, cytoskeleton, microtubule organizing center, centrosome
Function
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex. During mitosis, it mediates the ubiquitination and subsequent proteasomal degradation of AURKA, causing mitotic arrest. It also regulates mitochondrial function by mediating the ubiquitination and proteasomal degradation of the apoptosis inhibitor BIRC5.
Uniprot ID
Q9UJT9
Ensemble ID
ENST00000504595.2
HGNC ID
HGNC:13604

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.M1?; p.R306C .
COLO320 SNV: p.V482I .
CORL23 SNV: p.R143L .
DU145 SNV: p.R306C .
FADU SNV: p.R432P .
HCT15 SNV: p.G72S; p.T206A .
HT115 SNV: p.P118L .
KMRC1 SNV: p.I59M .
KYSE410 SNV: p.E259K .
LNCaP clone FGC SNV: p.P54S .
NCIH2172 Deletion: p.G15AfsTer9 .
NCIH358 SNV: p.P413S .
RL SNV: p.H296Q .
SW1271 SNV: p.W149C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C253(1.26)  LDD2268  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 BRX211 C253(1.26)  LDD2268  [1]
 LDCM0023  KB03 BRX211 C253(3.29)  LDD2685  [1]
 LDCM0024  KB05 BRX211 C253(1.45)  LDD3102  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840