Details of the Target

General Information of Target

Target ID LDTP13392
Target Name Sal-like protein 4 (SALL4)
Gene Name SALL4
Gene ID 57167
Synonyms
ZNF797; Sal-like protein 4; Zinc finger protein 797; Zinc finger protein SALL4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDLQGRGVPSIDRLRVLLMLFHTMAQIMAEQEVENLSGLSTNPEKDIFVVRENGTTCLMA
EFAAKFIVPYDVWASNYVDLITEQADIALTRGAEVKGRCGHSQSELQVFWVDRAYALKML
FVKESHNMSKGPEATWRLSKVQFVYDSSEKTHFKDAVSAGKHTANSHHLSALVTPAGKSY
ECQAQQTISLASSDPQKTVTMILSAVHIQPFDIISDFVFSEEHKCPVDEREQLEETLPLI
LGLILGLVIMVTLAIYHVHHKMTANQVQIPRDRSQYKHMG
Target Bioclass
Transcription factor
Family
Sal C2H2-type zinc-finger protein family
Subcellular location
Cytoplasm
Function Transcription factor with a key role in the maintenance and self-renewal of embryonic and hematopoietic stem cells.
Uniprot ID
Q9UJQ4
Ensemble ID
ENST00000217086.9
HGNC ID
HGNC:15924

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.L186P; p.S706F DBIA    Probe Info 
CCK81 Deletion: p.V995FfsTer14 .
HCT15 SNV: p.R586H .
HEC1 SNV: p.T350S; p.R905Q DBIA    Probe Info 
HEC1B SNV: p.R905Q .
HT115 SNV: p.R865Q .
KARPAS422 SNV: p.S307P .
LN229 SNV: p.P511T .
LS180 Deletion: p.V995FfsTer14 .
MCC13 SNV: p.P300S .
NB1 SNV: p.R865L .
NCIH1299 SNV: p.P127L .
NCIH2286 SNV: p.E150K; p.Q217H .
NCIH446 SNV: p.L998I .
OVK18 Deletion: p.V995FfsTer14 .
RL952 SNV: p.A297T .
SAOS2 SNV: p.R928L .
SNGM Deletion: p.V995FfsTer14 .
SNU1 Deletion: p.Q166RfsTer3 .
SNU308 SNV: p.T611I .
TC71 Substitution: p.V181M .
TE4 Deletion: p.R865HfsTer49
SNV: p.Q866Ter		 .
TOV21G SNV: p.P713H .
U937 Substitution: p.G454D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C577(1.50)  LDD3380  [1]
NAIA_5
 Probe Info  		N.A.  LDD2223  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A2780 C577(4.56)  LDD2254  [1]
 LDCM0023  KB03 A2780 C577(3.42)  LDD2671  [1]
 LDCM0024  KB05 OV-90 C577(1.50)  LDD3380  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264