Details of the Target

General Information of Target

Target ID LDTP13384
Target Name Regulating synaptic membrane exocytosis protein 3 (RIMS3)
Gene Name RIMS3
Gene ID 9783
Synonyms
KIAA0237; Regulating synaptic membrane exocytosis protein 3; Nim3; RIM3 gamma; Rab-3-interacting molecule 3; RIM 3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEETQPPPQPKLPLCDSLMIWLQTFNTASPCQDVKQLTSGVAMAQVLHQIDAAWFNESWL
SRIKEDVGDNWRIKASNVKKVLQGIMSYYHEFLGQQISEALIPDLNQITECSDPVELGRL
LQLILGCAINCEKKQEHIQNIMTLEESVQHVVMTAIQELMSKEILSSPPNDAVGELEQQL
KRALEELQEALAEKEELRQRCEELDMQVTTLQDEKNSLVSENEMMNEKLDQLDGSFDDPN
TVVAKKYFHAQLQLEQLQEENFRLEAAKDDYRVHCEELEKQLIEFQHRNDELTSLAEETR
ALKDEIDVLRATSDKANKLESTVEIYRQKLQDLNDLRKQVKTLQETNMMYMHNTVSLEEE
LKKANAARTQLETYKRQVQDLHVKLSSESKRADTLAFEMKRLEEKHEALLKEKERLIEQR
DTLKETNEELRCSQVQQDHLNQTDASATKSYENLAAEIMPVEYREVFIRLQHENKMLRLQ
QEGSENERIEELQEQLEQKHRKMNELETEQRLSKERIRELQQQIEDLQKSLQEQGSKSEG
ESSSKLKQKLEAHMEKLTEVHEELQKKQELIEDLQPDINQNVQKINELEAALQKKDEDMK
AMEERYKMYLEKARNVIKTLDPKLNPASAEIMLLRKQLAEKERRIEILESECKVAKFRDY
EEKLIVSAWYNKSLAFQKLGMESRLVSGGGACSDTGACTPARSFLAQQRHITNTRRNLSV
KVPATTSD
Target Bioclass
Other
Subcellular location
Synapse
Function Regulates synaptic membrane exocytosis.
Uniprot ID
Q9UJD0
Ensemble ID
ENST00000372683.1
HGNC ID
HGNC:21292

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
22RV1 SNV: p.R149Ter .
MOLT4 SNV: p.S81N .
NCIH1703 SNV: p.G234V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C28(2.77)  LDD3339  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 697 C218(1.30)  LDD2245  [1]
 LDCM0023  KB03 697 C218(1.49)  LDD2662  [1]
 LDCM0024  KB05 NALM-6 C28(2.77)  LDD3339  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840