Details of the Target

General Information of Target

Target ID LDTP13357
Target Name PHD finger protein 11 (PHF11)
Gene Name PHF11
Gene ID 51131
Synonyms
BCAP; PHD finger protein 11; BRCA1 C-terminus-associated protein; Renal carcinoma antigen NY-REN-34
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTWTSGQLQREKQARPGSGAVLAFPDDKDLRVYGPAESQSAVFGDVCPLLTSLLDGYNVC
VMAYGQTGSGKSYTMLGRHSDDGPVLPLDPQSDLGIIPRVAEELFRLILENTSRSPKVEV
SIVEVYNNDIFDLLAKDSIAAVSGVKREVVTAKDGRTEVALLASEAVGSASKLMELVHGG
LQLRAKHPTLVHADSSRSHLIITVTLTTASCSDSTADQACSATLPREQTEAGRAGRSRRA
SQGALAPQLVPGNPAGHAEQVQARLQLVDSAGSECVGVSGVTGLALREMACISRSLAALA
GVLGALLEHRGHAPYRNSRLTHLLQDCLGGDAKLLVILCISPSQRHLAQTLQGLGFGIRA
RQVQRGPARKKPPSSQTEGKRRPD
Target Bioclass
Other
Subcellular location
Nucleus
Function Positive regulator of Th1-type cytokine gene expression.
Uniprot ID
Q9UIL8
Ensemble ID
ENST00000357596.7
HGNC ID
HGNC:17024

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 Deletion: p.F59LfsTer7 .
HEC1B Deletion: p.F59LfsTer7 .
KO52 Deletion: p.K177_R178del .
MFE296 SNV: p.A264T .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C135(23.29)  LDD0209  [1]
IA-alkyne
 Probe Info  		C197(5.54)  LDD1705  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 697 C311(1.67)  LDD2245  [3]
 LDCM0023  KB03 Jurkat C135(23.29)  LDD0209  [1]
 LDCM0024  KB05 Reh C311(2.41)  LDD3403  [3]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
E3 ubiquitin-protein ligase TRIM41 (TRIM41) TRIM/RBCC family Q8WV44
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Syntenin-1 (SDCBP) . O00560
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Tektin-4 (TEKT4) Tektin family Q8WW24
Nuclear transport factor 2 (NUTF2) . P61970

References

1 Covalent Inhibition by a Natural Product-Inspired Latent Electrophile. J Am Chem Soc. 2023 May 24;145(20):11097-11109. doi: 10.1021/jacs.3c00598. Epub 2023 May 15.
2 An Activity-Guided Map of Electrophile-Cysteine Interactions in Primary Human T Cells. Cell. 2020 Aug 20;182(4):1009-1026.e29. doi: 10.1016/j.cell.2020.07.001. Epub 2020 Jul 29.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840