Details of the Target

General Information of Target

Target ID LDTP13346
Target Name Solute carrier organic anion transporter family member 3A1 (SLCO3A1)
Gene Name SLCO3A1
Gene ID 28232
Synonyms
OATP3A1; OATPD; SLC21A11; Solute carrier organic anion transporter family member 3A1; OATP3A1; Organic anion transporter polypeptide-related protein 3; OATP-RP3; OATPRP3; Organic anion-transporting polypeptide D; OATP-D; PGE1 transporter; Sodium-independent organic anion transporter D; Solute carrier family 21 member 11
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MILNWKLLGILVLCLHTRGISGSEGHPSHPPAEDREEAGSPTLPQGPPVPGDPWPGAPPL
FEDPPPTRPSRPWRDLPETGVWLPEPPRTDPPQPPRPDDPWPAGPQPPENPWPPAPEVDN
RPQEEPDLDPPREEYR
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Family
Organo anion transporter (TC 2.A.60) family
Subcellular location
Multi-pass membrane protein; Basolateral cell membrane; Basal cell membrane; Cell membrane
Function
Putative organic anion antiporter with apparent broad substrate specificity. Recognizes various substrates including thyroid hormone L-thyroxine, prostanoids such as prostaglandin E1 and E2, bile acids such as taurocholate, glycolate and glycochenodeoxycholate and peptide hormones such as L-arginine vasopressin, likely operating in a tissue-specific manner. The transport mechanism, its electrogenicity and potential tissue-specific counterions remain to be elucidated (Probable).
TTD ID
T99255
Uniprot ID
Q9UIG8
DrugMap ID
TT5CE6L
Ensemble ID
ENST00000318445.11
HGNC ID
HGNC:10952
ChEMBL ID
CHEMBL2073685

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
LN18 SNV: p.A510V .
LNCaP clone FGC SNV: p.Y98C; p.I545T .
MM1S SNV: p.N174I .
SNU1 SNV: p.A91V .
U937 SNV: p.R147C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TFBX
 Probe Info  		N.A.  LDD0148  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgi membrane protein 1 (GOLM1) GOLM family Q8NBJ4

The Drug(s) Related To This Target

Approved
Click To Hide/Show 10 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Alprostadil Small molecular drug DB00770
Benzylpenicillin Small molecular drug DB01053
Conjugated Estrogens Small molecular drug DB00286
Dinoprost Tromethamine Small molecular drug DB01160
Dinoprostone Small molecular drug DB00917
Iloprost Small molecular drug DB01088
Methotrexate Small molecular drug DB00563
Safinamide Small molecular drug DB06654
Taurocholic Acid Small molecular drug DB04348
Thyroid Porcine . DB09100
Investigative
Click To Hide/Show 2 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Lobeglitazone Small molecular drug DB09198
[3h]Estrone-3-sulphate Small molecular drug D04AXP

References

1 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255