Details of the Target

General Information of Target

Target ID LDTP13334
Target Name Cytohesin-4 (CYTH4)
Gene Name CYTH4
Gene ID 27128
Synonyms
CYT4; PSCD4; Cytohesin-4; PH, SEC7 and coiled-coil domain-containing protein 4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTTLTRQDLNFGQVVADVLCEFLEVAVHLILYVREVYPVGIFQKRKKYNVPVQMSCHPEL
NQYIQDTLHCVKPLLEKNDVEKVVVVILDKEHRPVEKFVFEITQPPLLSISSDSLLSHVE
QLLRAFILKISVCDAVLDHNPPGCTFTVLVHTREAATRNMEKIQVIKDFPWILADEQDVH
MHDPRLIPLKTMTSDILKMQLYVEERAHKGS
Target Bioclass
Other
Subcellular location
Cell membrane
Function Promotes guanine-nucleotide exchange on ARF1 and ARF5. Promotes the activation of ARF factors through replacement of GDP with GTP.
Uniprot ID
Q9UIA0
Ensemble ID
ENST00000248901.11
HGNC ID
HGNC:9505

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ATP probe
 Probe Info  		N.A.  LDD0199  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Proteasome subunit beta type-1 (PSMB1) Peptidase T1B family P20618
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Protein FosB (FOSB) BZIP family P53539
Other
Click To Hide/Show 12 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Connector enhancer of kinase suppressor of ras 1 (CNKSR1) CNKSR family Q969H4
Cancer/testis antigen 1 (CTAG1A; CTAG1B) CTAG/PCC1 family P78358
Keratin, type I cuticular Ha4 (KRT34) Intermediate filament family O76011
Keratin, type I cytoskeletal 16 (KRT16) Intermediate filament family P08779
Harmonin-binding protein USHBP1 (USHBP1) MCC family Q8N6Y0
Coiled-coil domain-containing protein 120 (CCDC120) . Q96HB5
Coiled-coil domain-containing protein 6 (CCDC6) . Q16204
Doublecortin domain-containing protein 2 (DCDC2) . Q9UHG0
Interactor protein for cytohesin exchange factors 1 (IPCEF1) . Q8WWN9
KN motif and ankyrin repeat domain-containing protein 2 (KANK2) . Q63ZY3
Protein hinderin (KIAA1328) . Q86T90
Uncharacterized protein CCDC197 (CCDC197) . Q8NCU1

References

1 Targeted Proteomic Approaches for Proteome-Wide Characterizations of the AMP-Binding Capacities of Kinases. J Proteome Res. 2022 Aug 5;21(8):2063-2070. doi: 10.1021/acs.jproteome.2c00225. Epub 2022 Jul 12.