Details of the Target

General Information of Target

Target ID LDTP13332
Target Name Catenin alpha-3 (CTNNA3)
Gene Name CTNNA3
Gene ID 29119
Synonyms
Catenin alpha-3; Alpha T-catenin; Cadherin-associated protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MIPASAKAPHKQPHKQSISIGRGTRKRDEDSGTEVGEGTDEWAQSKATVRPPDQLELTDA
ELKEEFTRILTANNPHAPQNIVRYSFKEGTYKPIGFVNQLAVHYTQVGNLIPKDSDEGRR
QHYRDELVAGSQESVKVISETGNLEEDEEPKELETEPGSQTDVPAAGAAEKVTEEELMTP
KQPKERKLTNQFNFSERASQTYNNPVRDRECQTEPPPRTNFSATANQWEIYDAYVEELEK
QEKTKEKEKAKTPVAKKSGKMAMRKLTSMESQTDDLIKLSQAAKIMERMVNQNTYDDIAQ
DFKYYDDAADEYRDQVGTLLPLWKFQNDKAKRLSVTALCWNPKYRDLFAVGYGSYDFMKQ
SRGMLLLYSLKNPSFPEYMFSSNSGVMCLDIHVDHPYLVAVGHYDGNVAIYNLKKPHSQP
SFCSSAKSGKHSDPVWQVKWQKDDMDQNLNFFSVSSDGRIVSWTLVKRKLVHIDVIKLKV
EGSTTEVPEGLQLHPVGCGTAFDFHKEIDYMFLVGTEEGKIYKCSKSYSSQFLDTYDAHN
MSVDTVSWNPYHTKVFMSCSSDWTVKIWDHTIKTPMFIYDLNSAVGDVAWAPYSSTVFAA
VTTDGKAHIFDLAINKYEAICNQPVAAKKNRLTHVQFNLIHPIIIVGDDRGHIISLKLSP
NLRKMPKEKKGQEVQKGPAVEIAKLDKLLNLVREVKIKT
Target Bioclass
Other
Family
Vinculin/alpha-catenin family
Subcellular location
Cytoplasm, cytoskeleton
Function May be involved in formation of stretch-resistant cell-cell adhesion complexes.
Uniprot ID
Q9UI47
Ensemble ID
ENST00000433211.7
HGNC ID
HGNC:2511

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAMA1 SNV: p.S344L .
CCK81 SNV: p.I447V .
DU145 SNV: p.H513Y .
HCT116 Deletion: p.K856NfsTer3 .
HCT15 SNV: p.A415T; p.E427D .
HT SNV: p.T454P; p.N816S .
HT115 SNV: p.R371K .
HUH7 SNV: p.T867S .
KATOIII SNV: p.P216L .
KMS11 SNV: p.Y775H .
MDAMB436 Deletion: p.R842GfsTer5 .
MEWO SNV: p.E326Q .
NCIH1793 Deletion: p.C113FfsTer20 .
OCUM1 SNV: p.A271E .
RL952 SNV: p.S56N; p.D695G .
WM2664 Insertion: p.E631RfsTer8 .
YSCCC SNV: p.L16M .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		N.A.  LDD2223  [1]

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264