Details of the Target

General Information of Target

Target ID LDTP13293
Target Name ATP-dependent RNA helicase DDX25 (DDX25)
Gene Name DDX25
Gene ID 29118
Synonyms
GRTH; ATP-dependent RNA helicase DDX25; EC 3.6.4.13; DEAD box protein 25; Gonadotropin-regulated testicular RNA helicase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MALQGISVVELSGLAPGPFCAMVLADFGARVVRVDRPGSRYDVSRLGRGKRSLVLDLKQP
RGAAVLRRLCKRSDVLLEPFRRGVMEKLQLGPEILQRENPRLIYARLSGFGQSGSFCRLA
GHDINYLALSGVLSKIGRSGENPYAPLNLLADFAGGGLMCALGIIMALFDRTRTGKGQVI
DANMVEGTAYLSSFLWKTQKLSLWEAPRGQNMLDGGAPFYTTYRTADGEFMAVGAIEPQF
YELLIKGLGLKSDELPNQMSMDDWPEMKKKFADVFAEKTKAEWCQIFDGTDACVTPVLTF
EEVVHHDHNKERGSFITSEEQDVSPRPAPLLLNTPAIPSFKRDPFIGEHTEEILEEFGFS
REEIYQLNSDKIIESNKVKASL
Target Bioclass
Enzyme
Family
DEAD box helicase family
Subcellular location
Cytoplasm
Function ATP-dependent RNA helicase. Required for mRNA export and translation regulation during spermatid development.
Uniprot ID
Q9UHL0
Ensemble ID
ENST00000263576.11
HGNC ID
HGNC:18698

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AGS SNV: p.V251A .
AN3CA SNV: p.I336V .
AU565 SNV: p.D482N .
HT115 SNV: p.H72Y; p.R242C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		N.A.  LDD2241  [1]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [1]

References

1 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853