Details of the Target

General Information of Target

Target ID LDTP13280
Target Name Doublecortin domain-containing protein 2 (DCDC2)
Gene Name DCDC2
Gene ID 51473
Synonyms
KIAA1154; RU2; Doublecortin domain-containing protein 2; Protein RU2S
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MVRKKNPPLRNVASEGEGQILEPIGTESKVSGKNKEFSADQMSENTDQSDAAELNHKEEH
SLHVQDPSSSSKKDLKSAVLSEKAGFNYESPSKGGNFPSFPHDEVTDRNMLAFSSPAAGG
VCEPLKSPQRAEADDPQDMACTPSGDSLETKEDQKMSPKATEETGQAQSGQANCQGLSPV
SVASKNPQVPSDGGVRLNKSKTDLLVNDNPDPAPLSPELQDFKCNICGYGYYGNDPTDLI
KHFRKYHLGLHNRTRQDAELDSKILALHNMVQFSHSKDFQKVNRSVFSGVLQDINSSRPV
LLNGTYDVQVTSGGTFIGIGRKTPDCQGNTKYFRCKFCNFTYMGNSSTELEQHFLQTHPN
KIKASLPSSEVAKPSEKNSNKSIPALQSSDSGDLGKWQDKITVKAGDDTPVGYSVPIKPL
DSSRQNGTEATSYYWCKFCSFSCESSSSLKLLEHYGKQHGAVQSGGLNPELNDKLSRGSV
INQNDLAKSSEGETMTKTDKSSSGAKKKDFSSKGAEDNMVTSYNCQFCDFRYSKSHGPDV
IVVGPLLRHYQQLHNIHKCTIKHCPFCPRGLCSPEKHLGEITYPFACRKSNCSHCALLLL
HLSPGAAGSSRVKHQCHQCSFTTPDVDVLLFHYESVHESQASDVKQEANHLQGSDGQQSV
KESKEHSCTKCDFITQVEEEISRHYRRAHSCYKCRQCSFTAADTQSLLEHFNTVHCQEQD
ITTANGEEDGHAISTIKEEPKIDFRVYNLLTPDSKMGEPVSESVVKREKLEEKDGLKEKV
WTESSSDDLRNVTWRGADILRGSPSYTQASLGLLTPVSGTQEQTKTLRDSPNVEAAHLAR
PIYGLAVETKGFLQGAPAGGEKSGALPQQYPASGENKSKDESQSLLRRRRGSGVFCANCL
TTKTSLWRKNANGGYVCNACGLYQKLHSTPRPLNIIKQNNGEQIIRRRTRKRLNPEALQA
EQLNKQQRGSNEEQVNGSPLERRSEDHLTESHQREIPLPSLSKYEAQGSLTKSHSAQQPV
LVSQTLDIHKRMQPLHIQIKSPQESTGDPGNSSSVSEGKGSSERGSPIEKYMRPAKHPNY
SPPGSPIEKYQYPLFGLPFVHNDFQSEADWLRFWSKYKLSVPGNPHYLSHVPGLPNPCQN
YVPYPTFNLPPHFSAVGSDNDIPLDLAIKHSRPGPTANGASKEKTKAPPNVKNEGPLNVV
KTEKVDRSTQDELSTKCVHCGIVFLDEVMYALHMSCHGDSGPFQCSICQHLCTDKYDFTT
HIQRGLHRNNAQVEKNGKPKE
Target Bioclass
Other
Subcellular location
Cell projection, cilium
Function
Protein that plays a role in the inhibition of canonical Wnt signaling pathway. May be involved in neuronal migration during development of the cerebral neocortex. Involved in the control of ciliogenesis and ciliary length.
Uniprot ID
Q9UHG0
Ensemble ID
ENST00000378450.6
HGNC ID
HGNC:18141

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
769P SNV: p.G264A .
FUOV1 Deletion: p.F225LfsTer6 .
NCIN87 SNV: p.Q417Ter .
SG231 SNV: p.T408S .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0232  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0109  NEM HeLa N.A.  LDD0232  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 7 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
tRNA (guanine(10)-N2)-methyltransferase homolog (TRMT11) TRM11 methyltransferase family Q7Z4G4
Ribonuclease P/MRP protein subunit POP5 (POP5) Eukaryotic/archaeal RNase P protein component 2 family Q969H6
Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase (B3GNT5) Glycosyltransferase 31 family Q9BYG0
NIF3-like protein 1 (NIF3L1) GTP cyclohydrolase I type 2/NIF3 family Q9GZT8
Mitochondrial genome maintenance exonuclease 1 (MGME1) MGME1 family Q9BQP7
MYG1 exonuclease (MYG1) MYG1 family Q9HB07
Guanine nucleotide-binding protein-like 3-like protein (GNL3L) TRAFAC class YlqF/YawG GTPase family Q9NVN8
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sodium-coupled neutral amino acid symporter 2 (SLC38A2) Amino acid/polyamine transporter 2 family Q96QD8
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger protein 432 (ZNF432) Krueppel C2H2-type zinc-finger protein family O94892
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
C5a anaphylatoxin chemotactic receptor 2 (C5AR2) G-protein coupled receptor 1 family Q9P296
Other
Click To Hide/Show 15 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Centromere protein O (CENPO) CENP-O/MCM21 family Q9BU64
Cyclin-dependent kinases regulatory subunit 1 (CKS1B) CKS family P61024
Dynein light chain Tctex-type protein 2 (DYNLT2) Dynein light chain Tctex-type family Q8IZS6
Protein FAM118A (FAM118A) FAM118 family Q9NWS6
Keratin-associated protein 5-9 (KRTAP5-9) KRTAP type 5 family P26371
Keratin-associated protein 9-3 (KRTAP9-3) KRTAP type 9 family Q9BYQ3
MORF4 family-associated protein 1 (MRFAP1) MORF4 family-associated protein family Q9Y605
Neuromedin-U (NMU) NmU family P48645
Toll-interacting protein (TOLLIP) Tollip family Q9H0E2
Oxytocin-neurophysin 1 (OXT) Vasopressin/oxytocin family P01178
COMM domain-containing protein 9 (COMMD9) . Q9P000
Cytohesin-4 (CYTH4) . Q9UIA0
HORMA domain-containing protein 1 (HORMAD1) . Q86X24
MICAL-like protein 2 (MICALL2) . Q8IY33
Protein tyrosine phosphatase receptor type C-associated protein (PTPRCAP) . Q14761

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.