Details of the Target

General Information of Target

Target ID LDTP13265
Target Name Contactin-associated protein-like 2 (CNTNAP2)
Gene Name CNTNAP2
Gene ID 26047
Synonyms
CASPR2; KIAA0868; Contactin-associated protein-like 2; Cell recognition molecule Caspr2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MKPTSGPEEARRPASDIRVFASNCSMHGLGHVFGPGSLSLRRGMWAAAVVLSVATFLYQV
AERVRYYREFHHQTALDERESHRLIFPAVTLCNINPLRRSRLTPNDLHWAGSALLGLDPA
EHAAFLRALGRPPAPPGFMPSPTFDMAQLYARAGHSLDDMLLDCRFRGQPCGPENFTTIF
TRMGKCYTFNSGADGAELLTTTRGGMGNGLDIMLDVQQEEYLPVWRDNEETPFEVGIRVQ
IHSQEEPPIIDQLGLGVSPGYQTFVSCQQQQLSFLPPPWGDCSSASLNPNYEPEPSDPLG
SPSPSPSPPYTLMGCRLACETRYVARKCGCRMVYMPGDVPVCSPQQYKNCAHPAIDAMLR
KDSCACPNPCASTRYAKELSMVRIPSRAAARFLARKLNRSEAYIAENVLALDIFFEALNY
ETVEQKKAYEMSELLGDIGGQMGLFIGASLLTILEILDYLCEVFRDKVLGYFWNRQHSQR
HSSTNLLQEGLGSHRTQVPHLSLGPRPPTPPCAVTKTLSASHRTCYLVTQL
Target Bioclass
Other
Family
Neurexin family
Subcellular location
Membrane
Function
Required for gap junction formation (Probable). Required, with CNTNAP1, for radial and longitudinal organization of myelinated axons. Plays a role in the formation of functional distinct domains critical for saltatory conduction of nerve impulses in myelinated nerve fibers. Demarcates the juxtaparanodal region of the axo-glial junction.
Uniprot ID
Q9UHC6
Ensemble ID
ENST00000361727.8
HGNC ID
HGNC:13830

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
786O SNV: p.I65R .
CAL120 Deletion: p.F415_D417delinsY
SNV: p.P1247S		 .
CMK SNV: p.T968S .
COLO792 SNV: p.S859A .
COLO800 SNV: p.A674V .
DU145 Insertion: p.K334QfsTer16
SNV: p.R147P;p.R160S		 .
EFO27 SNV: p.W458Ter .
FADU SNV: p.D822E .
G361 SNV: p.P739S .
HCC1187 SNV: p.T968S .
HCT15 SNV: p.R889M .
HELA SNV: p.I474L .
HKGZCC SNV: p.Y742Ter; p.R889S .
HT SNV: p.P60L .
HT115 SNV: p.D78Y .
HUH7 SNV: p.P163L .
ICC8 SNV: p.Q2H .
IGR1 SNV: p.P1244S .
IM95 SNV: p.A185T .
IPC298 SNV: p.M1312I .
KARPAS299 SNV: p.K710T .
KMCH1 SNV: p.L410M .
LN18 SNV: p.I1331N .
MELJUSO SNV: p.E149K .
MEWO SNV: p.K491Q .
NCIH1792 SNV: p.M942I .
NCIH1793 SNV: p.G787C .
NCIH2172 SNV: p.E177K .
NCIH2286 SNV: p.V195A; p.E582D .
NCIH358 SNV: p.D1103E .
OCUG1 SNV: p.S75A .
OE33 SNV: p.W718R .
RKN SNV: p.G72R .
RKO SNV: p.V1267I .
SISO SNV: p.V110A .
SW1271 SNV: p.D879G .
TC71 SNV: p.S1225L .
UACC62 SNV: p.G303R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TH211
 Probe Info  		Y1293(20.00)  LDD0260  [1]
PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0136  [2]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
DNA-directed RNA polymerase II subunit RPB7 (POLR2G) Eukaryotic RPB7/RPC8 RNA polymerase subunit family P62487
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Calnexin (CANX) Calreticulin family P27824
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Homeobox protein MOX-2 (MEOX2) . P50222
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Contactin-1 (CNTN1) Contactin family Q12860
Other
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Golgi reassembly-stacking protein 2 (GORASP2) GORASP family Q9H8Y8

References

1 Chemoproteomic profiling of kinases in live cells using electrophilic sulfonyl triazole probes. Chem Sci. 2021 Jan 21;12(9):3295-3307. doi: 10.1039/d0sc06623k.
2 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.