Details of the Target

General Information of Target

Target ID LDTP13231
Target Name Signal-transducing adaptor protein 2 (STAP2)
Gene Name STAP2
Gene ID 55620
Synonyms
BKS; Signal-transducing adaptor protein 2; STAP-2; Breast tumor kinase substrate; BRK substrate
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MIHELLLALSGYPGSIFTWNKRSGLQVSQDFPFLHPSETSVLNRLCRLGTDYIRFTEFIE
QYTGHVQQQDHHPSQQGQGGLHGIYLRAFCTGLDSVLQPYRQALLDLEQEFLGDPHLSIS
HVNYFLDQFQLLFPSVMVVVEQIKSQKIHGCQILETVYKHSCGGLPPVRSALEKILAVCH
GVMYKQLSAWMLHGLLLDQHEEFFIKQGPSSGNVSAQPEEDEEDLGIGGLTGKQLRELQD
LRLIEEENMLAPSLKQFSLRVEILPSYIPVRVAEKILFVGESVQMFENQNVNLTRKGSIL
KNQEDTFAAELHRLKQQPLFSLVDFEQVVDRIRSTVAEHLWKLMVEESDLLGQLKIIKDF
YLLGRGELFQAFIDTAQHMLKTPPTAVTEHDVNVAFQQSAHKVLLDDDNLLPLLHLTIEY
HGKEHKADATQAREGPSRETSPREAPASGWAALGLSYKVQWPLHILFTPAVLEKYNVVFK
YLLSVRRVQAELQHCWALQMQRKHLKSNQTDAIKWRLRNHMAFLVDNLQYYLQVDVLESQ
FSQLLHQINSTRDFESIRLAHDHFLSNLLAQSFILLKPVFHCLNEILDLCHSFCSLVSQN
LGPLDERGAAQLSILVKGFSRQSSLLFKILSSVRNHQINSDLAQLLLRLDYNKYYTQAGG
TLGSFGM
Target Bioclass
Other
Subcellular location
Cytoplasm
Function Substrate of protein kinase PTK6. May play a regulatory role in the acute-phase response in systemic inflammation and may modulate STAT3 activity.
Uniprot ID
Q9UGK3
Ensemble ID
ENST00000594605.6
HGNC ID
HGNC:30430

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
MOLT4 SNV: p.F39I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 6 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K239(10.00)  LDD0277  [1]
IPM
 Probe Info  		N.A.  LDD0241  [2]
DBIA
 Probe Info  		C172(1.33)  LDD3337  [3]
BTD
 Probe Info  		C32(0.81)  LDD2107  [4]
IA-alkyne
 Probe Info  		N.A.  LDD0163  [5]
NAIA_5
 Probe Info  		C153(0.00); C223(0.00)  LDD2223  [6]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0632  CL-Sc Hep-G2 C105(20.00); C153(20.00)  LDD2227  [6]
 LDCM0022  KB02 AGS C172(1.28)  LDD2263  [3]
 LDCM0023  KB03 AGS C172(1.86)  LDD2680  [3]
 LDCM0024  KB05 MSTO-211H C172(1.33)  LDD3337  [3]
 LDCM0514  Nucleophilic fragment 20a MDA-MB-231 C32(0.81)  LDD2107  [4]
 LDCM0532  Nucleophilic fragment 29a MDA-MB-231 C105(1.47)  LDD2125  [4]
 LDCM0536  Nucleophilic fragment 31 MDA-MB-231 C32(0.63)  LDD2129  [4]
 LDCM0542  Nucleophilic fragment 37 MDA-MB-231 C32(1.04)  LDD2135  [4]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C105(0.22)  LDD2140  [4]
 LDCM0552  Nucleophilic fragment 6a MDA-MB-231 C32(0.72)  LDD2146  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Inhibitor of nuclear factor kappa-B kinase subunit beta (IKBKB) Ser/Thr protein kinase family O14920
Tyrosine-protein kinase Blk (BLK) Tyr protein kinase family P51451
Tyrosine-protein kinase Yes (YES1) Tyr protein kinase family P07947
Tyrosine-protein kinase TXK (TXK) Tyr protein kinase family P42681
Other
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Kelch-like ECH-associated protein 1 (KEAP1) KEAP1 family Q14145
Myeloid differentiation primary response protein MyD88 (MYD88) . Q99836

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
4 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761
5 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
6 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264