Details of the Target

General Information of Target

Target ID LDTP13221
Target Name Inositol oxygenase (MIOX)
Gene Name MIOX
Gene ID 55586
Synonyms
ALDRL6; KSP32; RSOR; Inositol oxygenase; EC 1.13.99.1; Aldehyde reductase-like 6; Kidney-specific protein 32; Myo-inositol oxygenase; MI oxygenase; Renal-specific oxidoreductase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MATSVGHRCLGLLHGVAPWRSSLHPCEITALSQSLQPLRKLPFRAFRTDARKIHTAPART
MFLLRPLPILLVTGGGYAGYRQYEKYRERELEKLGLEIPPKLAGHWEVALYKSVPTRLLS
RAWGRLNQVELPHWLRRPVYSLYIWTFGVNMKEAAVEDLHHYRNLSEFFRRKLKPQARPV
CGLHSVISPSDGRILNFGQVKNCEVEQVKGVTYSLESFLGPRMCTEDLPFPPAASCDSFK
NQLVTREGNELYHCVIYLAPGDYHCFHSPTDWTVSHRRHFPGSLMSVNPGMARWIKELFC
HNERVVLTGDWKHGFFSLTAVGATNVGSIRIYFDRDLHTNSPRHSKGSYNDFSFVTHTNR
EGVPMRKGEHLGEFNLGSTIVLIFEAPKDFNFQLKTGQKIRFGEALGSL
Target Bioclass
Enzyme
Family
Myo-inositol oxygenase family
Subcellular location
Cytoplasm
Uniprot ID
Q9UGB7
Ensemble ID
ENST00000216075.11
HGNC ID
HGNC:14522

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
L428 SNV: p.W225Ter .
NCIH661 SNV: p.D263Y .
SNU1 SNV: p.G34D .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		N.A.  LDD0036  [1]

References

1 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853