Details of the Target
General Information of Target
| Target ID | LDTP13207 | |||||
|---|---|---|---|---|---|---|
| Target Name | Ephrin type-A receptor 6 (EPHA6) | |||||
| Gene Name | EPHA6 | |||||
| Gene ID | 285220 | |||||
| Synonyms |
EHK2; HEK12; Ephrin type-A receptor 6; EC 2.7.10.1; EPH homology kinase 2; EHK-2; EPH-like kinase 12; EK12 |
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| 3D Structure | ||||||
| Sequence |
MLRTCYVLCSQAGPPSRGWQSLSFDGGAFHLKGTGELTRALLVLRLCAWPPLVTHGLLLQ
AWSRRLLGSRLSGAFLRASVYGQFVAGETAEEVKGCVQQLRTLSLRPLLAVPTEEEPDSA AKSGEAWYEGNLGAMLRCVDLSRGLLEPPSLAEASLMQLKVTALTSTRLCKELASWVRRP GASLELSPERLAEAMDSGQNLQVSCLNAEQNQHLRASLSRLHRVAQYARAQHVRLLVDAE YTSLNPALSLLVAALAVRWNSPGEGGPWVWNTYQACLKDTFERLGRDAEAAHRAGLAFGV KLVRGAYLDKERAVAQLHGMEDPTQPDYEATSQSYSRCLELMLTHVARHGPMCHLMVASH NEESVRQATKRMWELGIPLDGTVCFGQLLGMCDHVSLALGQAGYVVYKSIPYGSLEEVIP YLIRRAQENRSVLQGARREQELLSQELWRRLLPGCRRIPH |
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| Target Type |
Literature-reported
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| Target Bioclass |
Enzyme
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| Family |
Protein kinase superfamily, Tyr protein kinase family, Ephrin receptor subfamily
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| Subcellular location |
Membrane
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| Function |
Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling.
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| TTD ID | ||||||
| Uniprot ID | ||||||
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| ChEMBL ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
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C690(1.99) | LDD3401 | [1] | |
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BTD Probe Info |
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C4(1.24) | LDD2089 | [2] | |
Competitor(s) Related to This Target
| Competitor ID | Name | Cell line | Binding Site(Ratio) | Interaction ID | Ref |
|---|---|---|---|---|---|
| LDCM0498 | BS-3668 | MDA-MB-231 | C4(1.18) | LDD2091 | [2] |
| LDCM0022 | KB02 | CC-LP-1 | C690(2.44) | LDD2298 | [1] |
| LDCM0023 | KB03 | CC-LP-1 | C690(3.06) | LDD2715 | [1] |
| LDCM0024 | KB05 | RD | C690(1.99) | LDD3401 | [1] |
| LDCM0496 | Nucleophilic fragment 11a | MDA-MB-231 | C4(1.24) | LDD2089 | [2] |
References