Details of the Target
General Information of Target
| Target ID | LDTP13183 | |||||
|---|---|---|---|---|---|---|
| Target Name | DNA repair protein REV1 (REV1) | |||||
| Gene Name | REV1 | |||||
| Gene ID | 51455 | |||||
| Synonyms |
REV1L; DNA repair protein REV1; EC 2.7.7.-; Alpha integrin-binding protein 80; AIBP80; Rev1-like terminal deoxycytidyl transferase |
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| 3D Structure | ||||||
| Sequence |
MLRVVSWNINGIRRPLQGVANQEPSNCAAVAVGRILDELDADIVCLQETKVTRDALTEPL
AIVEGYNSYFSFSRNRSGYSGVATFCKDNATPVAAEEGLSGLFATQNGDVGCYGNMDEFT QEELRALDSEGRALLTQHKIRTWEGKEKTLTLINVYCPHADPGRPERLVFKMRFYRLLQI RAEALLAAGSHVIILGDLNTAHRPIDHWDAVNLECFEEDPGRKWMDSLLSNLGCQSASHV GPFIDSYRCFQPKQEGAFTCWSAVTGARHLNYGSRLDYVLGDRTLVIDTFQASFLLPEVM GSDHCPVGAVLSVSSVPAKQCPPLCTRFLPEFAGTQLKILRFLVPLEQSPVLEQSTLQHN NQTRVQTCQNKAQVRSTRPQPSQVGSSRGQKNLKSYFQPSPSCPQASPDIELPSLPLMSA LMTPKTPEEKAVAKVVKGQAKTSEAKDEKELRTSFWKSVLAGPLRTPLCGGHREPCVMRT VKKPGPNLGRRFYMCARPRGPPTDPSSRCNFFLWSRPS |
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| Target Bioclass |
Enzyme
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| Family |
DNA polymerase type-Y family
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| Subcellular location |
Nucleus
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| Function |
Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.
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| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
| ChEMBL ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
STPyne Probe Info |
 |
K440(10.00) | LDD0277 | [1] | |
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IPM Probe Info |
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C366(0.60) | LDD2229 | [2] | |
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1d-yne Probe Info |
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N.A. | LDD0356 | [3] | |
The Interaction Atlas With This Target
References