Details of the Target

General Information of Target

Target ID LDTP13181
Target Name Heat shock protein beta-7 (HSPB7)
Gene Name HSPB7
Gene ID 27129
Synonyms
CVHSP; Heat shock protein beta-7; HspB7; Cardiovascular heat shock protein; cvHsp
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MNPASDGGTSESIFDLDYASWGIRSTLMVAGFVFYLGVFVVCHQLSSSLNATYRSLVARE
KVFWDLAATRAVFGVQSTAAGLWALLGDPVLHADKARGQQNWCWFHITTATGFFCFENVA
VHLSNLIFRTFDLFLVIHHLFAFLGFLGCLVNLQAGHYLAMTTLLLEMSTPFTCVSWMLL
KAGWSESLFWKLNQWLMIHMFHCRMVLTYHMWWVCFWHWDGLVSSLYLPHLTLFLVGLAL
LTLIINPYWTHKKTQQLLNPVDWNFAQPEAKSRPEGNGQLLRKKRP
Target Bioclass
Other
Family
Small heat shock protein (HSP20) family
Subcellular location
Cytoplasm
Uniprot ID
Q9UBY9
Ensemble ID
ENST00000311890.14
HGNC ID
HGNC:5249

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT116 SNV: p.M1? .
MM1S Substitution: p.D51S .
TE8 SNV: p.H124P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C131(1.14)  LDD2361  [1]
m-APA
 Probe Info  		N.A.  LDD2231  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 Hs 839.T C131(1.14)  LDD2361  [1]
 LDCM0023  KB03 Hs 839.T C131(19.83)  LDD2778  [1]
 LDCM0024  KB05 Hs 839.T C131(9.00)  LDD3195  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Global profiling of functional histidines in live cells using small-molecule photosensitizer and chemical probe relay labelling. Nat Chem. 2024 Jun 4. doi: 10.1038/s41557-024-01545-6. Online ahead of print.
Mass spectrometry data entry: PXD042377