Details of the Target

General Information of Target

Target ID LDTP13179
Target Name Lysophosphatidic acid receptor 3 (LPAR3)
Gene Name LPAR3
Gene ID 23566
Synonyms
EDG7; LPA3; Lysophosphatidic acid receptor 3; LPA receptor 3; LPA-3; Lysophosphatidic acid receptor Edg-7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEPLGNWRSLRAPLPPMLLLLLLQVAGPVGALAETLLNAPRAMGTSSSPPSPASVVAPGT
TLFEESRLPVFTLDYPHVQIPFEITLWILLASLAKIGFHLYHKLPTIVPESCLLIMVGLL
LGGIIFGVDEKSPPAMKTDVFFLYLLPPIVLDAGYFMPTRPFFENIGTIFWYAVVGTLWN
SIGIGVSLFGICQIEAFGLSDITLLQNLLFGSLISAVDPVAVLAVFENIHVNEQLYILVF
GESLLNDAVTVVLYNLFKSFCQMKTIETIDVFAGIANFFVVGIGGVLIGIFLGFIAAFTT
RFTHNIRVIEPLFVFLYSYLSYITAEMFHLSGIMAITACAMTMNKYVEENVSQKSYTTIK
YFMKMLSSVSETLIFIFMGVSTVGKNHEWNWAFVCFTLAFCLMWRALGVFVLTQVINRFR
TIPLTFKDQFIIAYGGLRGAICFALVFLLPAAVFPRKKLFITAAIVVIFFTVFILGITIR
PLVEFLDVKRSNKKQQAVSEEIYCRLFDHVKTGIEDVCGHWGHNFWRDKFKKFDDKYLRK
LLIRENQPKSSIVSLYKKLEIKHAIEMAETGMISTVPTFASLNDCREEKIRKVTSSETDE
IRELLSRNLYQIRQRTLSYNRHSLTADTSERQAKEILIRRRHSLRESIRKDSSLNREHRA
STSTSRYLSLPKNTKLPEKLQKRRTISIADGNSSDSDADAGTTVLNLQPRARRFLPEQFS
KKSPQSYKMEWKNEVDVDSGRDMPSTPPTPHSREKGTQTSGLLQQPLLSKDQSGSEREDS
LTEGIPPKPPPRLVWRASEPGSRKARFGSEKP
Target Type
Clinical trial
Target Bioclass
GPCR
Family
G-protein coupled receptor 1 family
Subcellular location
Cell membrane
Function
Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. May play a role in the development of ovarian cancer. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins.
TTD ID
T95923
Uniprot ID
Q9UBY5
DrugMap ID
TTE2YJR
Ensemble ID
ENST00000370611.4
HGNC ID
HGNC:14298
ChEMBL ID
CHEMBL3250

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD2156  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 8 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
rRNA methyltransferase 1, mitochondrial (MRM1) RNA methyltransferase TrmH family Q6IN84
Probable glutathione peroxidase 8 (GPX8) Glutathione peroxidase family Q8TED1
Glutathione S-transferase 3, mitochondrial (MGST3) MAPEG family O14880
Peroxynitrite isomerase THAP4 (THAP4) Nitrobindin family Q8WY91
ADP-ribosylation factor-like protein 13B (ARL13B) Arf family Q3SXY8
Phosphatidylcholine:ceramide cholinephosphotransferase 2 (SGMS2) Sphingomyelin synthase family Q8NHU3
Plasma membrane ascorbate-dependent reductase CYBRD1 (CYBRD1) . Q53TN4
Transmembrane ascorbate-dependent reductase CYB561 (CYB561) . P49447
Transporter and channel
Click To Hide/Show 14 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Sodium-dependent organic anion transporter (SLC10A6) Bile acid:sodium symporter (BASS) family Q3KNW5
Claudin-7 (CLDN7) Claudin family O95471
Membrane-associated progesterone receptor component 2 (PGRMC2) Cytochrome b5 family O15173
G protein-activated inward rectifier potassium channel 2 (KCNJ6) Inward rectifier-type potassium channel family P48051
LHFPL tetraspan subfamily member 5 protein (LHFPL5) LHFP family Q8TAF8
Aquaporin-6 (AQP6) MIP/aquaporin (TC 1.A.8) family Q13520
Membrane-spanning 4-domains subfamily A member 4A (MS4A4A) MS4A family Q96JQ5
Potassium voltage-gated channel subfamily C member 1 (KCNC1) Potassium channel family P48547
Sodium channel regulatory subunit beta-3 (SCN3B) Sodium channel auxiliary subunit SCN3B family Q9NY72
Leukocyte surface antigen CD53 (CD53) Tetraspanin (TM4SF) family P19397
Transmembrane protein 14B (TMEM14B) TMEM14 family Q9NUH8
Transmembrane protein 41A (TMEM41A) TMEM41 family Q96HV5
Transmembrane protein 70, mitochondrial (TMEM70) TMEM70 family Q9BUB7
Transmembrane protein 79 (TMEM79) . Q9BSE2
Transcription factor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cyclic AMP-responsive element-binding protein 3-like protein 1 (CREB3L1) BZIP family Q96BA8
GPCR
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Free fatty acid receptor 2 (FFAR2) G-protein coupled receptor 1 family O15552
Immunoglobulin
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
B-cell antigen receptor complex-associated protein alpha chain (CD79A) . P11912
Cytokine and receptor
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ectodysplasin-A (EDA) Tumor necrosis factor family Q92838
Other
Click To Hide/Show 20 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Bcl-2-like protein 13 (BCL2L13) Bcl-2 family Q9BXK5
Claudin-2 (CLDN2) Claudin family P57739
Claudin-9 (CLDN9) Claudin family O95484
NADH dehydrogenase 1 alpha subcomplex assembly factor 2 (NDUFAF2) Complex I NDUFA12 subunit family Q8N183
Complexin-4 (CPLX4) Complexin/synaphin family Q7Z7G2
Gap junction beta-5 protein (GJB5) Connexin family O95377
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) ERGIC family Q9Y282
Protein FAM209A (FAM209A) FAM209 family Q5JX71
Protein FAM210B, mitochondrial (FAM210B) FAM210 family Q96KR6
RAB6-interacting golgin (GORAB) GORAB family Q5T7V8
Protein jagunal homolog 1 (JAGN1) Jagunal family Q8N5M9
Leptin receptor overlapping transcript-like 1 (LEPROTL1) OB-RGRP/VPS55 family O95214
RELT-like protein 2 (RELL2) RELT family Q8NC24
Reticulophagy regulator 3 (RETREG3) RETREG family Q86VR2
Protein shisa-like-1 (SHISAL1) Shisa family Q3SXP7
Ankyrin repeat, SAM and basic leucine zipper domain-containing protein 1 (ASZ1) . Q8WWH4
Fibronectin type III domain-containing protein 9 (FNDC9) . Q8TBE3
Lck-interacting transmembrane adapter 1 (LIME1) . Q9H400
Transmembrane protein 52B (TMEM52B) . Q4KMG9
Transmembrane protein C16orf54 (C16orf54) . Q6UWD8

The Drug(s) Related To This Target

Phase 2
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Sar-100842 . D07WCT
Investigative
Click To Hide/Show 15 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
2-oleoyl-lpa Small molecular drug D0R2VH
Alkyl Ompt Small molecular drug D0X0OP
Alpha-fluoromethylenephosphonate Small molecular drug D0D5OY
Dioctanoylglycerol Pyrophosphate Small molecular drug D0G6XT
Dodecyl-thiophosphate Small molecular drug D04KQT
Dodecylphosphate Small molecular drug D0FZ6A
Ki16425 Small molecular drug D02LXI
Lpa Small molecular drug D0X0UR
Naepa Small molecular drug D0R8LB
Oleoyl-thiophosphate Small molecular drug D0K3GQ
Ompt Small molecular drug D0H6DZ
Pmid19800804c12 Small molecular drug D0SH0M
T13 Small molecular drug D0Z6DG
Vpc12249 Small molecular drug D0PI4H
Vpc32183 Small molecular drug D0S6CW

References

1 Benchmarking Cleavable Biotin Tags for Peptide-Centric Chemoproteomics. J Proteome Res. 2022 May 6;21(5):1349-1358. doi: 10.1021/acs.jproteome.2c00174. Epub 2022 Apr 25.
Mass spectrometry data entry: PXD031019