Details of the Target
General Information of Target
| Target ID | LDTP13176 | |||||
|---|---|---|---|---|---|---|
| Target Name | Kallikrein-11 (KLK11) | |||||
| Gene Name | KLK11 | |||||
| Gene ID | 11012 | |||||
| Synonyms |
PRSS20; TLSP; Kallikrein-11; hK11; EC 3.4.21.-; Hippostasin; Serine protease 20; Trypsin-like protease) [Cleaved into: Kallikrein-11 inactive chain 1; Kallikrein-11 inactive chain 2] |
|||||
| 3D Structure | ||||||
| Sequence |
MPGIKRILTVTILALCLPSPGNAQAQCTNGFDLDRQSGQCLDIDECRTIPEACRGDMMCV
NQNGGYLCIPRTNPVYRGPYSNPYSTPYSGPYPAAAPPLSAPNYPTISRPLICRFGYQMD ESNQCVDVDECATDSHQCNPTQICINTEGGYTCSCTDGYWLLEGQCLDIDECRYGYCQQL CANVPGSYSCTCNPGFTLNEDGRSCQDVNECATENPCVQTCVNTYGSFICRCDPGYELEE DGVHCSDMDECSFSEFLCQHECVNQPGTYFCSCPPGYILLDDNRSCQDINECEHRNHTCN LQQTCYNLQGGFKCIDPIRCEEPYLRISDNRCMCPAENPGCRDQPFTILYRDMDVVSGRS VPADIFQMQATTRYPGAYYIFQIKSGNEGREFYMRQTGPISATLVMTRPIKGPREIQLDL EMITVNTVINFRGSSVIRLRIYVSQYPF |
|||||
| Target Bioclass |
Enzyme
|
|||||
| Family |
Peptidase S1 family, Kallikrein subfamily
|
|||||
| Subcellular location |
Secreted; Golgi apparatus
|
|||||
| Function |
Possible multifunctional protease. Efficiently cleaves 'bz-Phe-Arg-4-methylcoumaryl-7-amide', a kallikrein substrate, and weakly cleaves other substrates for kallikrein and trypsin. Cleaves synthetic peptides after arginine but not lysine residues.
|
|||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
| ChEMBL ID | ||||||
Target Site Mutations in Different Cell Lines
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C83(0.80) | LDD3364 | [1] | |
Competitor(s) Related to This Target