Details of the Target

General Information of Target

Target ID LDTP13166
Target Name Beta-1,4-galactosyltransferase 7 (B4GALT7)
Gene Name B4GALT7
Gene ID 11285
Synonyms
XGALT1; Beta-1,4-galactosyltransferase 7; Beta-1,4-GalTase 7; Beta4Gal-T7; b4Gal-T7; EC 2.4.1.-; Proteoglycan UDP-galactose:beta-xylose beta1,4-galactosyltransferase I; UDP-Gal:beta-GlcNAc beta-1,4-galactosyltransferase 7; UDP-galactose:beta-N-acetylglucosamine beta-1,4-galactosyltransferase 7; UDP-galactose:beta-xylose beta-1,4-galactosyltransferase; XGPT; XGalT-1; Xylosylprotein 4-beta-galactosyltransferase; EC 2.4.1.133; Xylosylprotein beta-1,4-galactosyltransferase
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDRAALLGLARLCALWAALLVLFPYGAQGNWMWLGIASFGVPEKLGCANLPLNSRQKELC
KRKPYLLPSIREGARLGIQECGSQFRHERWNCMITAAATTAPMGASPLFGYELSSGTKET
AFIYAVMAAGLVHSVTRSCSAGNMTECSCDTTLQNGGSASEGWHWGGCSDDVQYGMWFSR
KFLDFPIGNTTGKENKVLLAMNLHNNEAGRQAVAKLMSVDCRCHGVSGSCAVKTCWKTMS
SFEKIGHLLKDKYENSIQISDKTKRKMRRREKDQRKIPIHKDDLLYVNKSPNYCVEDKKL
GIPGTQGRECNRTSEGADGCNLLCCGRGYNTHVVRHVERCECKFIWCCYVRCRRCESMTD
VHTCK
Target Bioclass
Enzyme
Family
Glycosyltransferase 7 family
Subcellular location
Golgi apparatus, Golgi stack membrane
Function Required for the biosynthesis of the tetrasaccharide linkage region of proteoglycans, especially for small proteoglycans in skin fibroblasts.
Uniprot ID
Q9UBV7
Ensemble ID
ENST00000029410.10
HGNC ID
HGNC:930

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C214(2.38)  LDD3310  [1]
IPM
 Probe Info  		C214(3.44)  LDD1702  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0213  Electrophilic fragment 2 MDA-MB-231 C214(3.44)  LDD1702  [2]
 LDCM0022  KB02 A2780 C214(1.67)  LDD2254  [1]
 LDCM0023  KB03 A2780 C214(2.58)  LDD2671  [1]
 LDCM0024  KB05 COLO792 C214(2.38)  LDD3310  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761