Details of the Target

General Information of Target

Target ID LDTP13149
Target Name Chemokine-like factor (CKLF)
Gene Name CKLF
Gene ID 51192
Synonyms
CKLF1; Chemokine-like factor; C32
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MLLETGLERDRARPGAAAVCTLGGTREIPLCAGCDQHILDRFILKALDRHWHSKCLKCSD
CHTPLAERCFSRGESVYCKDDFFKRFGTKCAACQLGIPPTQVVRRAQDFVYHLHCFACVV
CKRQLATGDEFYLMEDSRLVCKADYETAKQREAEATAKRPRTTITAKQLETLKSAYNTSP
KPARHVREQLSSETGLDMRVVQVWFQNRRAKEKRLKKDAGRQRWGQYFRNMKRSRGGSKS
DKDSVQEGQDSDAEVSFPDEPSLAEMGPANGLYGSLGEPTQALGRPSGALGNFSLEHGGL
AGPEQYRELRPGSPYGVPPSPAAPQSLPGPQPLLSSLVYPDTSLGLVPSGAPGGPPPMRV
LAGNGPSSDLSTGSSGGYPDFPASPASWLDEVDHAQF
Target Bioclass
Cytokine and receptor
Family
Chemokine-like factor family
Subcellular location
Secreted; Membrane
Function
May play an important role in inflammation and regeneration of skeletal muscle. Essential for embryonic development.; [Isoform 1]: Has chemotactic response in monocytes, neutrophils and lymphocytes. Binds CCR4.
Uniprot ID
Q9UBR5
Ensemble ID
ENST00000264001.9
HGNC ID
HGNC:13253

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
RL952 Deletion: p.E150KfsTer? .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K131(6.33); K148(1.92)  LDD0277  [1]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270