General Information of Target

Target ID LDTP13103
Target Name Cytokine SCM-1 beta (XCL2)
Gene Name XCL2
Gene ID 6846
Synonyms
SCYC2; Cytokine SCM-1 beta; C motif chemokine 2; XC chemokine ligand 2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEDKRSLSMARCEERNSRGQDHGLERVPFPPQLQSETYLHPADPSPAWDDPGSTGSPNLR
LLTEEIAFQPLAEEASFRRPHPDGDVPPQGEDNLLSLPFPQKLWRLVSSNQFSSIWWDDS
GACRVINQKLFEKEILKRDVAHKVFATTSIKSFFRQLNLYGFRKRRQCTFRTFTRIFSAK
RLVSILNKLEFYCHPYFQRDSPHLLVRMKRRVGVKSAPRHQEEDKPEAAGSCLAPADTEQ
QDHTSPNENDQVTPQHREPAGPNTQIRSGSAPPATPVMVPDSAVASDNSPVTQPAGEWSE
GSQAHVTPVAAVPGPAALPFLYVPGSPTQMNSYGPVVALPTASRSTLAMDTTGLPAPGML
PFCHLWVPVTLVAAGAAQPAASMVMFPHLPALHHHCPHSHRTSQYMPASDGPQAYPDYAD
QST
Target Bioclass
Cytokine and receptor
Family
Intercrine gamma family
Subcellular location
Secreted
Function Chemotactic activity for lymphocytes but not for monocytes or neutrophils.
Uniprot ID
Q9UBD3
Ensemble ID
ENST00000367819.3
HGNC ID
HGNC:10646

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info 
C69(3.12)  LDD2355  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 HG-3 C69(3.12)  LDD2355  [1]
 LDCM0023  KB03 HG-3 C69(4.75)  LDD2772  [1]
 LDCM0024  KB05 HG-3 C69(5.06)  LDD3189  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840