Details of the Target

General Information of Target

Target ID LDTP13101
Target Name Small proline-rich protein 3 (SPRR3)
Gene Name SPRR3
Gene ID 6707
Synonyms
SPRC; Small proline-rich protein 3; 22 kDa pancornulin; Cornifin beta; Esophagin
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAPPSVPLVLLLVLLLSLAETPASAPAHRGRGGWTLNSAGYLLGPVLHLPQMGDQDGKRE
TALEILDLWKAIDGLPYSHPPQPSKRNVMETFAKPEIGDLGMLSMKIPKEEDVLKS
Target Bioclass
Other
Family
Cornifin (SPRR) family
Subcellular location
Cytoplasm
Function Cross-linked envelope protein of keratinocytes.
Uniprot ID
Q9UBC9
Ensemble ID
ENST00000295367.5
HGNC ID
HGNC:11268
ChEMBL ID
CHEMBL4295970

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 3 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C153(2.14)  LDD3364  [1]
IA-alkyne
 Probe Info  		N.A.  LDD0162  [2]
ATP probe
 Probe Info  		N.A.  LDD0035  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 ABC-1 C66(2.34)  LDD2262  [1]
 LDCM0023  KB03 ABC-1 C66(1.66)  LDD2679  [1]
 LDCM0024  KB05 NCI-N87 C153(2.14)  LDD3364  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
3 Comparison of Quantitative Mass Spectrometry Platforms for Monitoring Kinase ATP Probe Uptake in Lung Cancer. J Proteome Res. 2018 Jan 5;17(1):63-75. doi: 10.1021/acs.jproteome.7b00329. Epub 2017 Nov 22.
Mass spectrometry data entry: PXD006095 , PXD006096