Details of the Target

General Information of Target

Target ID LDTP13078
Target Name Neurexin-2 (NRXN2)
Gene Name NRXN2
Gene ID 9379
Synonyms
KIAA0921; Neurexin-2; Neurexin II-alpha; Neurexin-2-alpha
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAASMFYGRLVAVATLRNHRPRTAQRAAAQVLGSSGLFNNHGLQVQQQQQRNLSLHEYMS
MELLQEAGVSVPKGYVAKSPDEAYAIAKKLGSKDVVIKAQVLAGGRGKGTFESGLKGGVK
IVFSPEEAKAVSSQMIGKKLFTKQTGEKGRICNQVLVCERKYPRREYYFAITMERSFQGP
VLIGSSHGGVNIEDVAAESPEAIIKEPIDIEEGIKKEQALQLAQKMGFPPNIVESAAENM
VKLYSLFLKYDATMIEINPMVEDSDGAVLCMDAKINFDSNSAYRQKKIFDLQDWTQEDER
DKDAAKANLNYIGLDGNIGCLVNGAGLAMATMDIIKLHGGTPANFLDVGGGATVHQVTEA
FKLITSDKKVLAILVNIFGGIMRCDVIAQGIVMAVKDLEIKIPVVVRLQGTRVDDAKALI
ADSGLKILACDDLDEAARMVVKLSEIVTLAKQAHVDVKFQLPI
Target Bioclass
Other
Family
Neurexin family
Subcellular location
Presynaptic cell membrane
Function Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.
Uniprot ID
Q9P2S2
Ensemble ID
ENST00000265459.11
HGNC ID
HGNC:8009

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CASKI SNV: p.S1068L .
CHL1 Substitution: p.D638P .
DETROIT562 SNV: p.R831C .
EFO27 Deletion: p.G1621AfsTer8
SNV: p.R759H		 .
HCC1937 SNV: p.D1301N .
HT SNV: p.T1615A .
IM95 SNV: p.R759H .
JURKAT Insertion: p.I574HfsTer12 .
KPL1 SNV: p.Q1173K .
KYSE180 SNV: p.G276D .
MCF7 SNV: p.Q1173K .
MFE319 SNV: p.T220A; p.A270G .
MKN1 SNV: p.R598Q .
MOLT4 SNV: p.Q415Ter; p.T435I; p.A950T; p.P1135S .
NCIH2286 SNV: p.H1226N .
NCIH358 SNV: p.A1646S .
ONS76 SNV: p.P212R .
RKO SNV: p.V591G; p.D1429G .
RL952 SNV: p.P1434L .
SKMEL2 SNV: p.T1515I .
SNU1 SNV: p.F447V .
YSCCC SNV: p.T1022I .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IPM
 Probe Info  		N.A.  LDD0147  [1]

References

1 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255