Details of the Target

General Information of Target

Target ID LDTP13054
Target Name Protein turtle homolog A (IGSF9)
Gene Name IGSF9
Gene ID 57549
Synonyms
IGSF9A; KIAA1355; NRT1; Protein turtle homolog A; Immunoglobulin superfamily member 9A; IgSF9A
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTSIIKLTTLSGVQEESALCYLLQVDEFRFLLDCGWDEHFSMDIIDSLRKHVHQIDAVLL
SHPDPLHLGALPYAVGKLGLNCAIYATIPVYKMGQMFMYDLYQSRHNTEDFTLFTLDDVD
AAFDKIQQLKFSQIVNLKGKGHGLSITPLPAGHMIGGTIWKIVKDGEEEIVYAVDFNHKR
EIHLNGCSLEMLSRPSLLITDSFNATYVQPRRKQRDEQLLTNVLETLRGDGNVLIAVDTA
GRVLELAQLLDQIWRTKDAGLGVYSLALLNNVSYNVVEFSKSQVEWMSDKLMRCFEDKRN
NPFQFRHLSLCHGLSDLARVPSPKVVLASQPDLECGFSRDLFIQWCQDPKNSIILTYRTT
PGTLARFLIDNPSEKITEIELRKRVKLEGKELEEYLEKEKLKKEAAKKLEQSKEADIDSS
DESDIEEDIDQPSAHKTKHDLMMKGEGSRKGSFFKQAKKSYPMFPAPEERIKWDEYGEII
KPEDFLVPELQATEEEKSKLESGLTNGDEPMDQDLSDVPTKCISTTESIEIKARVTYIDY
EGRSDGDSIKKIINQMKPRQLIIVHGPPEASQDLAECCRAFGGKDIKVYMPKLHETVDAT
SETHIYQVRLKDSLVSSLQFCKAKDAELAWIDGVLDMRVSKVDTGVILEEGELKDDGEDS
EMQVEAPSDSSVIAQQKAMKSLFGDDEKETGEESEIIPTLEPLPPHEVPGHQSVFMNEPR
LSDFKQVLLREGIQAEFVGGVLVCNNQVAVRRTETGRIGLEGCLCQDFYRIRDLLYEQYA
IV
Target Bioclass
Immunoglobulin
Family
Immunoglobulin superfamily, Turtle family
Subcellular location
Cell membrane
Function Functions in dendrite outgrowth and synapse maturation.
Uniprot ID
Q9P2J2
Ensemble ID
ENST00000361509.7
HGNC ID
HGNC:18132

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.R868Q .
AU565 SNV: p.Q103E DBIA    Probe Info 
CAL27 SNV: p.T725P .
CALU1 SNV: p.T679I .
COLO320 SNV: p.R59G .
COLO792 SNV: p.A802T; p.A1144V .
EFO27 SNV: p.Y204C .
HEC1 SNV: p.A1000T .
HT29 SNV: p.R767C .
HUH1 SNV: p.T403P .
IGR1 SNV: p.V268I .
Ishikawa (Heraklio) 02 ER Deletion: p.Q863RfsTer65 .
JURKAT SNV: p.S394F; p.L1163Q .
KNS42 SNV: p.A984V .
KYSE410 SNV: p.P446S .
LNCaP clone FGC SNV: p.E431K .
MEWO SNV: p.E426K; p.E1148K .
MOLT4 SNV: p.V37M .
NUGC3 SNV: p.P857L .
PEO1 SNV: p.A496P .
SAOS2 SNV: p.Q275H .
TOV21G Deletion: p.R978GfsTer9 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C846(2.98)  LDD3365  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 AU565 C846(1.57)  LDD2265  [1]
 LDCM0023  KB03 AU565 C846(1.96)  LDD2682  [1]
 LDCM0024  KB05 OVCAR-3 C846(2.98)  LDD3365  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840