Details of the Target

General Information of Target

Target ID LDTP13048
Target Name Kelch-like protein 14 (KLHL14)
Gene Name KLHL14
Gene ID 57565
Synonyms
KIAA1384; Kelch-like protein 14; Protein interactor of Torsin-1A; Printor; Protein interactor of torsinA
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGNTTTKFRKALINGDENLACQIYENNPQLKESLDPNTSYGEPYQHNTPLHYAARHGMNK
ILGTFLGRDGNPNKRNVHNETSMHLLCMGPQIMISEGALHPRLARPTEDDFRRADCLQMI
LKWKGAKLDQGEYERAAIDAVDNKKNTPLHYAAASGMKACVELLVKHGGDLFAENENKDT
PCDCAEKQHHKDLALNLESQMVFSRDPEAEEIEAEYAALDKREPYEGLRPQDLRRLKDML
IVETADMLQAPLFTAEALLRAHDWDREKLLEAWMSNPENCCQRSGVQMPTPPPSGYNAWD
TLPSPRTPRTTRSSVTSPDEISLSPGDLDTSLCDICMCSISVFEDPVDMPCGHDFCRGCW
ESFLNLKIQEGEAHNIFCPAYDCFQLVPVDIIESVVSKEMDKRYLQFDIKAFVENNPAIK
WCPTPGCDRAVRLTKQGSNTSGSDTLSFPLLRAPAVDCGKGHLFCWECLGEAHEPCDCQT
WKNWLQKITEMKPEELVGVSEAYEDAANCLWLLTNSKPCANCKSPIQKNEGCNHMQCAKC
KYDFCWICLEEWKKHSSSTGGYYRCTRYEVIQHVEEQSKEMTVEAEKKHKRFQELDRFMH
YYTRFKNHEHSYQLEQRLLKTAKEKMEQLSRALKETEGGCPDTTFIEDAVHVLLKTRRIL
KCSYPYGFFLEPKSTKKEIFELMQTDLEMVTEDLAQKVNRPYLRTPRHKIIKAACLVQQK
RQEFLASVARGVAPADSPEAPRRSFAGGTWDWEYLGFASPEEYAEFQYRRRHRQRRRGDV
HSLLSNPPDPDEPSESTLDIPEGGSSSRRPGTSVVSSASMSVLHSSSLRDYTPASRSENQ
DSLQALSSLDEDDPNILLAIQLSLQESGLALDEETRDFLSNEASLGAIGTSLPSRLDSVP
RNTDSPRAALSSSELLELGDSLMRLGAENDPFSTDTLSSHPLSEARSDFCPSSSDPDSAG
QDPNINDNLLGNIMAWFHDMNPQSIALIPPATTEISADSQLPCIKDGSEGVKDVELVLPE
DSMFEDASVSEGRGTQIEENPLEENILAGEAASQAGDSGNEAANRGDGSDVSSQTPQTSS
DWLEQVHLV
Target Bioclass
Other
Subcellular location
Cytoplasm, cytosol
Uniprot ID
Q9P2G3
Ensemble ID
ENST00000358095.4
HGNC ID
HGNC:29266

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL51 SNV: p.L374V .
DU145 SNV: p.W404C .
EFO21 SNV: p.E603Ter .
HCC15 SNV: p.D296E .
HCT15 SNV: p.P92S .
HEC1B SNV: p.F305S .
HT115 SNV: p.L568I .
HUH7 SNV: p.Y397C .
IGR1 Deletion: p.H389TfsTer40
SNV: p.K388N		 .
IGROV1 Deletion: p.R120GfsTer28 .
KYSE410 SNV: p.E380K .
MDAMB231 SNV: p.G77V .
MEWO SNV: p.G583R .
NCIH1666 SNV: p.M410T .
NCIH2286 SNV: p.A467T .
NCIH23 SNV: p.H464N .
OPM2 SNV: p.L610Ter .
REH SNV: p.S9P; p.E233K .
RKO Deletion: p.V232WfsTer30 .
RPMI8226 SNV: p.G576E .
SW948 SNV: p.Q411K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C290(1.32)  LDD3339  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 EFO-27 C54(1.62)  LDD2322  [1]
 LDCM0023  KB03 JeKo-1 C290(1.85)  LDD2820  [1]
 LDCM0024  KB05 NALM-6 C290(1.32)  LDD3339  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840