Details of the Target
General Information of Target
| Target ID | LDTP13008 | |||||
|---|---|---|---|---|---|---|
| Target Name | Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 (HCN3) | |||||
| Gene Name | HCN3 | |||||
| Gene ID | 57657 | |||||
| Synonyms |
KIAA1535; Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3 |
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| 3D Structure | ||||||
| Sequence |
MEESPLSRAPSRGGVNFLNVARTYIPNTKVECHYTLPPGTMPSASDWIGIFKVEAACVRD
YHTFVWSSVPESTTDGSPIHTSVQFQASYLPKPGAQLYQFRYVNRQGQVCGQSPPFQFRE PRPMDELVTLEEADGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSR VQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTI SEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDL KEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKAT LLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVE AEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALR VLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEAAVGLSCPAALTDSE DESPEDMRLPPYGLCERGDPGSSPAGPREASPLVVISQPAPISPHLSGPAEDSSSDSEAE DEKSVLMAAVQSGGEEANLLLPELGSAFYDMASGFTVGTLSETSTGGPATPTWKECPICK ERFPAESDKDALEDHMDGHFFFSTQDPFTFE |
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| Target Bioclass |
Transporter and channel
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| Family |
Potassium channel HCN family
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| Subcellular location |
Cell membrane
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| Function | Hyperpolarization-activated potassium channel. May also facilitate the permeation of sodium ions. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
| ChEMBL ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
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W1 Probe Info |
 |
N.A. | LDD0236 | [1] | |