Details of the Target

General Information of Target

Target ID LDTP12991
Target Name Voltage-dependent T-type calcium channel subunit alpha-1I (CACNA1I)
Gene Name CACNA1I
Gene ID 8911
Synonyms
KIAA1120; Voltage-dependent T-type calcium channel subunit alpha-1I; Voltage-gated calcium channel subunit alpha Cav3.3; Ca(v)3.3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDGSRRVRATSVLPRYGPPCLFKGHLSTKSNAFCTDSSSLRLSTLQLVKNHMAVHYNKIL
SAKAAVDCSVPVSVSTSIKYADQQRREKLKKELAQCEKEFKLTKTAMRANYKNNSKSLFN
TLQKPSGEPQIEDDMLKEEMNGFSSFARSLVPSSERLHLSLHKSSKVITNGPEKNSSSSP
SSVDYAASGPRKLSSGALYGRRPRSTFPNSHRFQLVISKAPSGDLLDKHSELFSNKQLPF
TPRTLKTEAKSFLSQYRYYTPAKRKKDFTDQRIEAETQTELSFKSELGTAETKNMTDSEM
NIKQASNCVTYDAKEKIAPLPLEGHDSTWDEIKDDALQHSSPRAMCQYSLKPPSTRKIYS
DEEELLYLSFIEDVTDEILKLGLFSNRFLERLFERHIKQNKHLEEEKMRHLLHVLKVDLG
CTSEENSVKQNDVDMLNVFDFEKAGNSEPNELKNESEVTIQQERQQYQKALDMLLSAPKD
ENEIFPSPTEFFMPIYKSKHSEGVIIQQVNDETNLETSTLDENHPSISDSLTDRETSVNV
IEGDSDPEKVEISNGLCGLNTSPSQSVQFSSVKGDNNHDMELSTLKIMEMSIEDCPLDV
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Family
Calcium channel alpha-1 subunit (TC 1.A.1.11) family, CACNA1I subfamily
Subcellular location
Membrane
Function
Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. This channel gives rise to T-type calcium currents. T-type calcium channels belong to the 'low-voltage activated (LVA)' group and are strongly blocked by nickel and mibefradil. A particularity of this type of channels is an opening at quite negative potentials, and a voltage-dependent inactivation. T-type channels serve pacemaking functions in both central neurons and cardiac nodal cells and support calcium signaling in secretory cells and vascular smooth muscle. They may also be involved in the modulation of firing patterns of neurons which is important for information processing as well as in cell growth processes. Gates in voltage ranges similar to, but higher than alpha 1G or alpha 1H.
TTD ID
T79694
Uniprot ID
Q9P0X4
DrugMap ID
TTQZFTH
Ensemble ID
ENST00000401624.5
HGNC ID
HGNC:1396
ChEMBL ID
CHEMBL5558

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL120 SNV: p.R634C .
CCK81 Deletion: p.F1317del .
DU145 SNV: p.L1702M .
HCC1143 SNV: p.I73M .
HCT116 SNV: p.V1595L .
HCT15 SNV: p.H2123Y .
HEC1 SNV: p.K297N; p.L2077M; p.S2102Y .
HEC1B SNV: p.K297N; p.L2077M .
HT Substitution: p.I719N .
IGROV1 Deletion: p.R935DfsTer23 .
JHH4 SNV: p.G566C .
JURKAT SNV: p.R743C .
KYSE410 SNV: p.L1764V .
LNCaP clone FGC SNV: p.I674T; p.H1048Y .
MCC13 SNV: p.G864D .
MEWO SNV: p.D1063N .
MFE319 SNV: p.S839T; p.T2156I .
MOLT4 SNV: p.A2T; p.V135G .
NCIH1155 SNV: p.M363I .
NCIH23 SNV: p.P2141Q .
NUGC3 SNV: p.R1449H .
REH SNV: p.A2114E .
RKO Deletion: p.P32HfsTer57 .
RPMI8226 SNV: p.G2116S .
SKMEL30 SNV: p.M1730I .
SW620 SNV: p.D1804G .
TE8 SNV: p.S313R .
TOV21G SNV: p.W984R; p.H1041N .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Acrolein
 Probe Info  		N.A.  LDD0217  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0109  NEM HeLa N.A.  LDD0227  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Transporter and channel
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Cation channel sperm-associated protein 1 (CATSPER1) Cation channel sperm-associated (TC 1.A.1.19) family Q8NEC5
Cation channel sperm-associated protein 2 (CATSPER2) Cation channel sperm-associated (TC 1.A.1.19) family Q96P56

The Drug(s) Related To This Target

Approved
Click To Hide/Show 22 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Amiodarone Small molecular drug DB01118
Amlodipine Small molecular drug DB00381
Calcium Phosphate Small molecular drug DB11348
Calcium Phosphate Dihydrate Small molecular drug DB14481
Cannabidiol Small molecular drug DB09061
Cinnarizine Small molecular drug DB00568
Enflurane Small molecular drug DB00228
Ergocalciferol Small molecular drug DB00153
Flunarizine Small molecular drug DB04841
Manidipine Small molecular drug DB09238
Nicardipine Small molecular drug DB00622
Nifedipine Small molecular drug DB01115
Nilvadipine Small molecular drug DB06712
Paramethadione Small molecular drug DB00617
Spironolactone Small molecular drug DB00421
Trimebutine Small molecular drug DB09089
Verapamil Small molecular drug DB00661
Zonisamide Small molecular drug DB00909
Bioallethrin . DB13746
Butamben . DB11148
Calcium Citrate . DB11093
Nylidrin . DB06152
Investigative
Click To Hide/Show 6 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
Mibefradil Small molecular drug DB01388
Ml218 Small molecular drug D09PWJ
Nabiximols Small molecular drug DB14011
Benidipine . DB09231
Efonidipine . DB09235
Medical Cannabis . DB14009
Discontinued
Click To Hide/Show 1 Drug(s) Interacting with This Target
Drug Name Drug Type External ID
U-92032 Small molecular drug D0OW2O

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.