Details of the Target

General Information of Target

Target ID LDTP12990
Target Name Spermatogenesis-associated protein 7 (SPATA7)
Gene Name SPATA7
Gene ID 55812
Synonyms
HSD3; Spermatogenesis-associated protein 7; HSD-3.1; Spermatogenesis-associated protein HSD3
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSHGPKQPGAAAAPAGGKAPGQHGGFVVTVKQERGEGPRAGEKGSHEEEPVKKRGWPKGK
KRKKILPNGPKAPVTGYVRFLNERREQIRTRHPDLPFPEITKMLGAEWSKLQPTEKQRYL
DEAEREKQQYMKELRAYQQSEAYKMCTEKIQEKKIKKEDSSSGLMNTLLNGHKGGDCDGF
STFDVPIFTEEFLDQNKAREAELRRLRKMNVAFEEQNAVLQRHTQSMSSARERLEQELAL
EERRTLALQQQLQAVRQALTASFASLPVPGTGETPTLGTLDFYMARLHGAIERDPAQHEK
LIVRIKEILAQVASEHL
Target Bioclass
Other
Subcellular location
Cytoplasm, cytoskeleton, cilium axoneme
Function
Involved in the maintenance of both rod and cone photoreceptor cells. It is required for recruitment and proper localization of RPGRIP1 to the photoreceptor connecting cilium (CC), as well as photoreceptor-specific localization of proximal CC proteins at the distal CC. Maintenance of protein localization at the photoreceptor-specific distal CC is essential for normal microtubule stability and to prevent photoreceptor degeneration.
Uniprot ID
Q9P0W8
Ensemble ID
ENST00000045347.11
HGNC ID
HGNC:20423

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
LN18 SNV: p.E92K .
OVTOKO SNV: p.E99K .
TE4 SNV: p.Q347H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C308(0.89)  LDD1511  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0281  AC21 HEK-293T C308(1.09)  LDD1520  [1]
 LDCM0289  AC29 HEK-293T C308(1.00)  LDD1528  [1]
 LDCM0298  AC37 HEK-293T C308(1.29)  LDD1537  [1]
 LDCM0307  AC45 HEK-293T C308(1.00)  LDD1546  [1]
 LDCM0312  AC5 HEK-293T C308(0.88)  LDD1551  [1]
 LDCM0316  AC53 HEK-293T C308(1.07)  LDD1555  [1]
 LDCM0325  AC61 HEK-293T C308(1.14)  LDD1564  [1]
 LDCM0248  AKOS034007472 HEK-293T C308(0.89)  LDD1511  [1]
 LDCM0409  CL21 HEK-293T C308(1.02)  LDD1613  [1]
 LDCM0422  CL33 HEK-293T C308(1.02)  LDD1626  [1]
 LDCM0435  CL45 HEK-293T C308(1.07)  LDD1639  [1]
 LDCM0448  CL57 HEK-293T C308(1.08)  LDD1651  [1]
 LDCM0461  CL69 HEK-293T C308(1.05)  LDD1664  [1]
 LDCM0475  CL81 HEK-293T C308(1.14)  LDD1678  [1]
 LDCM0484  CL9 HEK-293T C308(1.23)  LDD1687  [1]
 LDCM0488  CL93 HEK-293T C308(1.01)  LDD1691  [1]

References

1 Accelerating multiplexed profiling of protein-ligand interactions: High-throughput plate-based reactive cysteine profiling with minimal input. Cell Chem Biol. 2024 Mar 21;31(3):565-576.e4. doi: 10.1016/j.chembiol.2023.11.015. Epub 2023 Dec 19.
Mass spectrometry data entry: PXD044402