General Information of Target

Target ID LDTP12976
Target Name Mitochondrial transcription rescue factor 1 (MTRES1)
Gene Name MTRES1
Gene ID 51250
Synonyms
C6orf203; Mitochondrial transcription rescue factor 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASYFDEHDCEPSDPEQETRTNMLLELARSLFNRMDFEDLGLVVDWDHHLPPPAAKTVVE
NLPRTVIRGSQAELKCPVCLLEFEEEETAIEMPCHHLFHSSCILPWLSKTNSCPLCRYEL
PTDDDTYEEHRRDKARKQQQQHRLENLHGAMYT
Target Bioclass
Other
Subcellular location
Mitochondrion matrix
Function
Mitochondrial RNA-binding protein involved in mitochondrial transcription regulation. Functions as a protective factor to maintain proper mitochondrial RNA level during stress. Acts at the transcription level and its protective function depends on its RNA binding ability. Part of a mitoribosome-associated quality control pathway that prevents aberrant translation by responding to interruptions during elongation. As heterodimer with MTRF, ejects the unfinished nascent chain and peptidyl transfer RNA (tRNA), respectively, from stalled ribosomes. Recruitment of mitoribosome biogenesis factors to these quality control intermediates suggests additional roles for MTRES1 and MTRF during mitoribosome rescue.
Uniprot ID
Q9P0P8
Ensemble ID
ENST00000311381.8
HGNC ID
HGNC:17971

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Probe 1
 Probe Info 
Y164(20.20)  LDD3495  [1]

References

1 An Azo Coupling-Based Chemoproteomic Approach to Systematically Profile the Tyrosine Reactivity in the Human Proteome. Anal Chem. 2021 Jul 27;93(29):10334-10342. doi: 10.1021/acs.analchem.1c01935. Epub 2021 Jul 12.