Details of the Target

General Information of Target

Target ID LDTP12972
Target Name Transmembrane protein 216 (TMEM216)
Gene Name TMEM216
Gene ID 51259
Synonyms
Transmembrane protein 216
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSGRSGKKKMSKLSRSARAGVIFPVGRLMRYLKKGTFKYRISVGAPVYMAAVIEYLAAEI
LELAGNAARDNKKARIAPRHILLAVANDEELNQLLKGVTIASGGVLPRIHPELLAKKRGT
KGKSETILSPPPEKRGRKATSGKKGGKKSKAAKPRTSKKSKPKDSDKEGTSNSTSEDGPG
DGFTILSSKSLVLGQKLSLTQSDISHIGSMRVEGIVHPTTAEIDLKEDIGKALEKAGGKE
FLETVKELRKSQGPLEVAEAAVSQSSGLAAKFVIHCHIPQWGSDKCEEQLEETIKNCLSA
AEDKKLKSVAFPPFPSGRNCFPKQTAAQVTLKAISAHFDDSSASSLKNVYFLLFDSESIG
IYVQEMAKLDAK
Target Bioclass
Other
Subcellular location
Membrane
Function Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition.
Uniprot ID
Q9P0N5
Ensemble ID
ENST00000334888.10
HGNC ID
HGNC:25018

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT115 SNV: p.F75C .
PF382 SNV: p.N55S .
SNU1 SNV: p.L107P .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C83(3.65)  LDD3456  [1]
BTD
 Probe Info  		C83(0.51)  LDD2140  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 22RV1 C83(1.76)  LDD2243  [1]
 LDCM0023  KB03 Hs 578T C83(5.73)  LDD2777  [1]
 LDCM0024  KB05 SW1990 C83(3.65)  LDD3456  [1]
 LDCM0546  Nucleophilic fragment 40 MDA-MB-231 C83(0.51)  LDD2140  [2]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840
2 Nucleophilic covalent ligand discovery for the cysteine redoxome. Nat Chem Biol. 2023 Nov;19(11):1309-1319. doi: 10.1038/s41589-023-01330-5. Epub 2023 May 29.
Mass spectrometry data entry: PXD039908 , PXD029761