Details of the Target

General Information of Target

Target ID LDTP12935
Target Name Killer cell lectin-like receptor subfamily F member 1 (KLRF1)
Gene Name KLRF1
Gene ID 51348
Synonyms
CLEC5C; ML; Killer cell lectin-like receptor subfamily F member 1; Lectin-like receptor F1; Activating coreceptor NKp80; C-type lectin domain family 5 member C
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MTGRDSLSDGRTSSRALVPGGSPRGSRPRGFAITDLLGLEAELPAPAGPGQGSGCEGPAV
APCPGPGLDGSSLARGALPLGLGLLCGFGTQPPAAARAPCLLLADVPFLPPRGPEPAAPL
APSRPPPALGRQKRSDSVSTSDEDSQSEDRNDLKASPTLGKRKKRRHRTVFTAHQLEELE
KAFSEAHYPDVYAREMLAVKTELPEDRIQVWFQNRRAKWRKREKRWGGSSVMAEYGLYGA
MVRHCIPLPDSVLNSAEGGLLGSCAPWLLGMHKKSMGMIRKPGSEDKLAGLWGSDHFKEG
SSQSESGSQRGSDKVSPENGLEDVAIDLSSSARQETKKVHPGAGAQGGSNSTALEGPQPG
KVGAT
Target Bioclass
Other
Subcellular location
Membrane
Function Involved in the natural killer (NK)-mediated cytolysis of PHA-induced lymphoblasts.
Uniprot ID
Q9NZS2
Ensemble ID
ENST00000279545.7
HGNC ID
HGNC:13342

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CAL148 Insertion: p.L10FfsTer19 .
JHH1 SNV: p.A20T .
KURAMOCHI SNV: p.H148R .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K16(12.79)  LDD2217  [1]

References

1 Global profiling of lysine reactivity and ligandability in the human proteome. Nat Chem. 2017 Dec;9(12):1181-1190. doi: 10.1038/nchem.2826. Epub 2017 Jul 31.