Details of the Target

General Information of Target

Target ID LDTP12921
Target Name Interleukin-1 receptor accessory protein-like 1 (IL1RAPL1)
Gene Name IL1RAPL1
Gene ID 11141
Synonyms
OPHN4; Interleukin-1 receptor accessory protein-like 1; IL-1-RAPL-1; IL-1RAPL-1; IL1RAPL-1; EC 3.2.2.6; Oligophrenin-4; Three immunoglobulin domain-containing IL-1 receptor-related 2; TIGIRR-2; X-linked interleukin-1 receptor accessory protein-like 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAEASRWHRGGASKHKLHYRKEVEITTTLQELLLYFIFLINLCILTFGMVNPHMYYLNKV
MSSLFLDTSVPGEERTNFKSIRSITDFWKFMEGPLLEGLYWDSWYNNQQLYNLKNSSRIY
YENILLGVPRVRQLKVRNNTCKVYSSFQSLMSECYGKYTSANEDLSNFGLQINTEWRYST
SNTNSPWHWGFLGVYRNGGYIFTLSKSKSETKNKFIDLRLNSWITRGTRVIFIDFSLYNA
NVNLFCIIRLVAEFPATGGILTSWQFYSVKLLRYVSYYDYFIASCEITFCIFLFVFTTQE
VKKIKEFKSAYFKSIWNWLELLLLLLCFVAVSFNTYYNVQIFLLLGQLLKSTEKYSDFYF
LACWHIYYNNIIAITIFFAWIKIFKFISFNKTMSQLSSTLSRCVKDIVGFAIMFFIIFFA
YAQLGFLVFGSQVDDFSTFQNSIFAQFRIVLGDFNFAGIQQANPILGPIYFITFIFFVFF
VLLNMFLAIINDTYSEVKADYSIGRRLDFELGKMIKQSYKNVLEKFRLKKAQKDEDKKTK
GSGDLAEQARREGFDENEIQNAEQMKKWKERLEKKYYSMEIQDDYQPVTQEEFRELFLYA
VELEKELHYINLKLNQVVRKVSAL
Target Bioclass
Enzyme
Family
Interleukin-1 receptor family
Subcellular location
Cell membrane
Function
May regulate secretion and presynaptic differentiation through inhibition of the activity of N-type voltage-gated calcium channel. May activate the MAP kinase JNK. Plays a role in neurite outgrowth. During dendritic spine formation can bidirectionally induce pre- and post-synaptic differentiation of neurons by trans-synaptically binding to PTPRD.
Uniprot ID
Q9NZN1
Ensemble ID
ENST00000378993.6
HGNC ID
HGNC:5996

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
CCK81 SNV: p.L368P; p.I590T .
HEC1B SNV: p.D29G .
HT115 SNV: p.R50Ter; p.D276Y .
JURKAT SNV: p.E558G .
MCC13 SNV: p.S163L .
MCC26 SNV: p.W283Ter .
MEWO SNV: p.E161K; p.R352Q .
NCIH1793 SNV: p.E669D .
OPM2 SNV: p.P177S .
RL952 SNV: p.A675V .
SKOV3 SNV: p.S79C .
SNGM SNV: p.R390M .
SNU1 SNV: p.G443R .

Probe(s) Labeling This Target

PAL-AfBPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STS-1
 Probe Info  		N.A.  LDD0136  [1]

References

1 Design and synthesis of minimalist terminal alkyne-containing diazirine photo-crosslinkers and their incorporation into kinase inhibitors for cell- and tissue-based proteome profiling. Angew Chem Int Ed Engl. 2013 Aug 12;52(33):8551-6. doi: 10.1002/anie.201300683. Epub 2013 Jun 10.