Details of the Target

General Information of Target

Target ID LDTP12880
Target Name Proline-rich protein 13 (PRR13)
Gene Name PRR13
Gene ID 54458
Synonyms
TXR1; Proline-rich protein 13; Taxane-resistance protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MASTISAYKEKMKELSVLSLICSCFYTQPHPNTVYQYGDMEVKQLDKRASGQSFEVILKS
PSDLSPESPMLSSPPKKKDTSLEELQKRLEAAEERRKTQEAQVLKQLAERREHEREVLHK
ALEENNNFSRQAEEKLNYKMELSKEIREAHLAALRERLREKELHAAEVRRNKEQREEMSG
Target Bioclass
Other
Subcellular location
Nucleus
Function Negatively regulates TSP1 expression at the level of transcription. This down-regulation was shown to reduce taxane-induced apoptosis.
Uniprot ID
Q9NZ81
Ensemble ID
ENST00000379786.8
HGNC ID
HGNC:24528

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HT115 SNV: p.I88L .
NUGC3 Deletion: p.H49MfsTer43 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K131(4.55)  LDD0277  [1]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270