Details of the Target

General Information of Target

Target ID LDTP12823
Target Name Dynein axonemal heavy chain 9 (DNAH9)
Gene Name DNAH9
Gene ID 1770
Synonyms
DNAH17L; DNEL1; KIAA0357; Dynein axonemal heavy chain 9; Axonemal beta dynein heavy chain 9; Ciliary dynein heavy chain 9
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAELQMLLEEEIPGGRRALFDSYTNLERVADYCENNYIQSADKQRALEETKAYTTQSLAS
VAYLINTLANNVLQMLDIQASQLRRMESSINHISQTVDIHKEKVARREIGILTTNKNTSR
THKIIAPANLERPVRYIRKPIDYTILDDIGHGVKWLLRFKVSTQNMKMGGLPRTTPPTQK
PPSPPMSGKGTLGRHSPYRTLEPVRPPVVPNDYVPSPTRNMAPSQQSPVRTASVNQRNRT
YSSSGSSGGSHPSSRSSSRENSGSGSVGVPIAVPTPSPPSVFPAPAGSAGTPPLPATSAS
APAPLVPATVPSSTAPNAAAGGAPNLADGFTSPTPPVVSSTPPTGHPVQFYSMNRPASRH
TPPTIGGSLPYRRPPSITSQTSLQNQMNGGPFYSQNPVSDTPPPPPPVEEPVFDESPPPP
PPPEDYEEEEAAVVEYSDPYAEEDPPWAPRSYLEKVVAIYDYTKDKEDELSFQEGAIIYV
IKKNDDGWYEGVMNGVTGLFPGNYVESIMHYSE
Target Bioclass
Other
Family
Dynein heavy chain family
Subcellular location
Cytoplasm, cytoskeleton, cilium axoneme
Function
Force generating protein required for cilia beating in respiratory epithelia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP.
Uniprot ID
Q9NYC9
Ensemble ID
ENST00000262442.9
HGNC ID
HGNC:2953

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2058 SNV: p.E2775K .
A498 SNV: p.Q2948L .
AU565 SNV: p.S208P .
CAL78 SNV: p.I1579F .
COLO678 Deletion: p.L611GfsTer36 .
COLO679 SNV: p.R1926Ter .
CORL23 SNV: p.G3179V .
DOTC24510 SNV: p.E4258V .
DU145 SNV: p.R685S .
FADU SNV: p.R3485G .
GB1 SNV: p.D2389E .
HCC1395 SNV: p.D2653H .
HCC15 SNV: p.H156N; p.R4248S .
HCT116 SNV: p.L503H; p.D978N; p.A2054V; p.P4077S .
HEC1 SNV: p.Q170Ter; p.I3961V .
HT SNV: p.D3105N; p.I3476N .
HT115 SNV: p.E714D; p.D809N .
HT3 Deletion: p.V4087EfsTer16 .
JHH7 Substitution: p.H340S .
LNCaP clone FGC SNV: p.E1898V .
LS180 SNV: p.I4012V .
LU65 SNV: p.S4042F .
MCC26 Deletion: p.T2557RfsTer25 .
MDST8 SNV: p.E3620K .
MELJUSO SNV: p.P2338S .
MEWO SNV: p.S2280F; p.S2485L; p.K3532I; p.Q3659Ter .
MFE319 SNV: p.L1462M .
MIAPACA2 SNV: p.S3592R .
MM1S SNV: p.L4278I .
MOLT4 SNV: p.A986S .
NCIH146 SNV: p.N4351D .
NCIH1793 SNV: p.L492I; p.Q2858K .
NCIH2172 SNV: p.K1135R; p.E1375Ter; p.K1426R .
NCIH23 SNV: p.L4030M .
NUGC3 SNV: p.C2354Y .
ONS76 SNV: p.Q3034E .
OPM2 SNV: p.R4393W .
OVCAR5 SNV: p.T1874R .
OVK18 SNV: p.Q3840R .
PC14 SNV: p.Q1951Ter .
RL952 SNV: p.D1467G .
SKMEL24 SNV: p.P3996L .
SKMEL30 SNV: p.G1685A .
SW1271 SNV: p.K3873N .
T98G SNV: p.D207H .
TE11 SNV: p.C1821G .
TE4 SNV: p.D2360N .
TOV21G SNV: p.L2140I .
U87MG SNV: p.S835Y .
WM115 SNV: p.S3043F .
WM2664 SNV: p.S3043F .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		N.A.  LDD0166  [1]
NAIA_5
 Probe Info  		N.A.  LDD2225  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0632  CL-Sc Hep-G2 C2030(20.00)  LDD2227  [2]

References

1 SP3-FAIMS Chemoproteomics for High-Coverage Profiling of the Human Cysteinome*. Chembiochem. 2021 May 14;22(10):1841-1851. doi: 10.1002/cbic.202000870. Epub 2021 Feb 18.
Mass spectrometry data entry: PXD023056 , PXD023059 , PXD023058 , PXD023057 , PXD023060
2 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264