Details of the Target

General Information of Target

Target ID LDTP12816
Target Name Gamma-2-syntrophin (SNTG2)
Gene Name SNTG2
Gene ID 54221
Synonyms
Gamma-2-syntrophin; G2SYN; Syntrophin-5; SYN5
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSVGRRRIKLLGILMMANVFIYFIMEVSKSSSQEKNGKGEVIIPKEKFWKISTPPEAYWN
REQEKLNRQYNPILSMLTNQTGEAGRLSNISHLNYCEPDLRVTSVVTGFNNLPDRFKDFL
LYLRCRNYSLLIDQPDKCAKKPFLLLAIKSLTPHFARRQAIRESWGQESNAGNQTVVRVF
LLGQTPPEDNHPDLSDMLKFESEKHQDILMWNYRDTFFNLSLKEVLFLRWVSTSCPDTEF
VFKGDDDVFVNTHHILNYLNSLSKTKAKDLFIGDVIHNAGPHRDKKLKYYIPEVVYSGLY
PPYAGGGGFLYSGHLALRLYHITDQVHLYPIDDVYTGMCLQKLGLVPEKHKGFRTFDIEE
KNKNNICSYVDLMLVHSRKPQEMIDIWSQLQSAHLKC
Target Bioclass
Other
Family
Syntrophin family
Subcellular location
Cell membrane, sarcolemma
Function
Adapter protein that binds to and probably organizes the subcellular localization of a variety of proteins. May link various receptors to the actin cytoskeleton and the dystrophin glycoprotein complex.
Uniprot ID
Q9NY99
Ensemble ID
ENST00000308624.10
HGNC ID
HGNC:13741

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
C32 SNV: p.G450E .
CORL88 SNV: p.G64E .
HCC44 SNV: p.Q501H .
HT115 SNV: p.D527G .
KMCH1 SNV: p.D383G .
LNCaP clone FGC SNV: p.V74A .
LS180 SNV: p.T458A .
MELJUSO SNV: p.G178E .
NCIH2172 SNV: p.K356Ter .
NCIH661 SNV: p.G251R .
NCIH716 SNV: p.D146Y .
RT112 SNV: p.V357A .
SHP77 SNV: p.M286V .
SISO SNV: p.L122H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
ONAyne
 Probe Info  		K238(8.33)  LDD0274  [1]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270