Details of the Target

General Information of Target

Target ID LDTP12815
Target Name N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2 (B3GNT2)
Gene Name B3GNT2
Gene ID 10678
Synonyms
B3GALT7; B3GNT1; N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2; EC 2.4.1.149; Beta-1,3-N-acetylglucosaminyltransferase 1; BGnT-1; Beta-1,3-Gn-T1; Beta3Gn-T1; Beta-1,3-galactosyltransferase 7; Beta-1,3-GalTase 7; Beta3Gal-T7; Beta3GalT7; b3Gal-T7; Beta-3-Gx-T7; UDP-Gal:beta-GlcNAc beta-1,3-galactosyltransferase 7; UDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 2; BGnT-2; Beta-1,3-Gn-T2; Beta-1,3-N-acetylglucosaminyltransferase 2; Beta3Gn-T2; UDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase 7
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MEDSEALGFEHMGLDPRLLQAVTDLGWSRPTLIQEKAIPLALEGKDLLARARTGSGKTAA
YAIPMLQLLLHRKATGPVVEQAVRGLVLVPTKELARQAQSMIQQLATYCARDVRVANVSA
AEDSVSQRAVLMEKPDVVVGTPSRILSHLQQDSLKLRDSLELLVVDEADLLFSFGFEEEL
KSLLCHLPRIYQAFLMSATFNEDVQALKELILHNPVTLKLQESQLPGPDQLQQFQVVCET
EEDKFLLLYALLKLSLIRGKSLLFVNTLERSYRLRLFLEQFSIPTCVLNGELPLRSRCHI
ISQFNQGFYDCVIATDAEVLGAPVKGKRRGRGPKGDKASDPEAGVARGIDFHHVSAVLNF
DLPPTPEAYIHRAGRTARANNPGIVLTFVLPTEQFHLGKIEELLSGENRGPILLPYQFRM
EEIEGFRYRCRDAMRSVTKQAIREARLKEIKEELLHSEKLKTYFEDNPRDLQLLRHDLPL
HPAVVKPHLGHVPDYLVPPALRGLVRPHKKRKKLSSSCRKAKRAKSQNPLRSFKHKGKKF
RPTAKPS
Target Bioclass
Enzyme
Family
Glycosyltransferase 31 family
Subcellular location
Golgi apparatus membrane
Function
Beta-1,3-N-acetylglucosaminyltransferase involved in the synthesis of poly-N-acetyllactosamine. Catalyzes the initiation and elongation of poly-N-acetyllactosamine chains. Shows a marked preference for Gal(beta1-4)Glc(NAc)-based acceptors. Probably constitutes the main polylactosamine synthase.
Uniprot ID
Q9NY97
Ensemble ID
ENST00000301998.5
HGNC ID
HGNC:15629

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2058 SNV: p.S30T .
CCK81 SNV: p.R86G .
HCT15 SNV: p.E62Q .
MOLT4 SNV: p.V334I .
RT112 SNV: p.K351E .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
NAIA_5
 Probe Info  		C397(0.00); C367(0.00)  LDD2223  [1]

References

1 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264