Details of the Target

General Information of Target

Target ID LDTP12797
Target Name Stabilin-1 (STAB1)
Gene Name STAB1
Gene ID 23166
Synonyms
FEEL1; KIAA0246; Stabilin-1; Fasciclin, EGF-like, laminin-type EGF-like and link domain-containing scavenger receptor 1; FEEL-1; MS-1 antigen
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MSFRGGGRGGFNRGGGGGGFNRGGSSNHFRGGGGGGGGGNFRGGGRGGFGRGGGRGGFNK
GQDQGPPERVVLLGEFLHPCEDDIVCKCTTDENKVPYFNAPVYLENKEQIGKVDEIFGQL
RDFYFSVKLSENMKASSFKKLQKFYIDPYKLLPLQRFLPRPPGEKGPPRGGGRGGRGGGR
GGGGRGGGRGGGFRGGRGGGGGGFRGGRGGGFRGRGH
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Subcellular location
Membrane
Function
Acts as a scavenger receptor for acetylated low density lipoprotein. Binds to both Gram-positive and Gram-negative bacteria and may play a role in defense against bacterial infection. When inhibited in endothelial tube formation assays, there is a marked decrease in cell-cell interactions, suggesting a role in angiogenesis. Involved in the delivery of newly synthesized CHID1/SI-CLP from the biosynthetic compartment to the endosomal/lysosomal system.
TTD ID
T67246
Uniprot ID
Q9NY15
DrugMap ID
TTJFEOC
Ensemble ID
ENST00000321725.10
HGNC ID
HGNC:18628

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.A2420V .
CCFSTTG1 Substitution: p.S1447F .
HCC1395 SNV: p.H1573P .
HCT116 Deletion: p.V800CfsTer113; p.P978LfsTer57 .
HCT15 SNV: p.P1543S .
HDMYZ SNV: p.A2214S .
HEC1 SNV: p.Q731R .
HT115 SNV: p.N2311D .
HT1197 SNV: p.S1827F .
IM95 Deletion: p.V800CfsTer113 .
JURKAT SNV: p.M819I; p.C891Y; p.S1741N .
LNCaP clone FGC SNV: p.D384Y; p.W495Ter; p.C815Y; p.G854V .
LS180 SNV: p.G1177D .
MDAMB453 SNV: p.S2244C .
MDST8 SNV: p.E450K; p.P1671Q .
MELJUSO SNV: p.D1103G .
MFE296 SNV: p.A2401V .
MFE319 SNV: p.V1021A .
MOLT4 SNV: p.C332Y; p.G1534D; p.P1905L .
NCIH1703 SNV: p.G969R .
NCIH358 SNV: p.G2412R .
NCIH661 SNV: p.G1586R .
OVK18 Deletion: p.P978LfsTer57;p.G2143AfsTer9
SNV: p.G942D		 .
PF382 SNV: p.V2476A .
RKO Deletion: p.P978LfsTer57 .
SNGM SNV: p.C1356R .
SNU423 SNV: p.D2138G .
SW403 SNV: p.A2346S .
SW756 SNV: p.Q364H .
SW837 SNV: p.A1159P .
TCCSUP SNV: p.S1210Y .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C1260(1.22)  LDD3338  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 K052 C1260(2.31)  LDD2427  [1]
 LDCM0023  KB03 K052 C1260(2.47)  LDD2844  [1]
 LDCM0024  KB05 MV4-11 C1260(1.22)  LDD3338  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840