Details of the Target

General Information of Target

Target ID LDTP12765
Target Name Zinc finger and SCAN domain-containing protein 32 (ZSCAN32)
Gene Name ZSCAN32
Gene ID 54925
Synonyms
ZNF434; Zinc finger and SCAN domain-containing protein 32; Human cervical cancer suppressor gene 5 protein; HCCS-5; Zinc finger protein 434
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MGGTTSTRRVTFEADENENITVVKGIRLSENVIDRMKESSPSGSKSQRYSGAYGASVSDE
ELKRRVAEELALEQAKKESEDQKRLKQAKELDRERAAANEQLTRAILRERICSEEERAKA
KHLARQLEEKDRVLKKQDAFYKEQLARLEERSSEFYRVTTEQYQKAAEEVEAKFKRYESH
PVCADLQAKILQCYRENTHQTLKCSALATQYMHCVNHAKQSMLEKGG
Target Bioclass
Transcription factor
Family
Krueppel C2H2-type zinc-finger protein family
Subcellular location
Nucleus
Function May be involved in transcriptional regulation.
Uniprot ID
Q9NX65
Ensemble ID
ENST00000304926.7
HGNC ID
HGNC:20812

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
AN3CA SNV: p.L236I .
HCT15 SNV: p.P229S; p.G669D .
HEC1 SNV: p.V97A; p.E430D .
HEC1B SNV: p.V97A .
JURKAT SNV: p.I626T .
MDAMB453 SNV: p.E667V .
PC9 SNV: p.Q64Ter .
SKMEL30 SNV: p.P477L .
SW756 SNV: p.Q22H .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
Methacrolein
 Probe Info  		N.A.  LDD0218  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
TNF receptor-associated factor 2 (TRAF2) TNF receptor-associated factor family Q12933
Transcription factor
Click To Hide/Show 6 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Zinc finger and SCAN domain-containing protein 12 (ZSCAN12) Krueppel C2H2-type zinc-finger protein family O43309
Zinc finger and SCAN domain-containing protein 22 (ZSCAN22) Krueppel C2H2-type zinc-finger protein family P10073
Zinc finger and SCAN domain-containing protein 32 (ZSCAN32) Krueppel C2H2-type zinc-finger protein family Q9NX65
Zinc finger protein 24 (ZNF24) Krueppel C2H2-type zinc-finger protein family P17028
Zinc finger protein with KRAB and SCAN domains 1 (ZKSCAN1) Krueppel C2H2-type zinc-finger protein family P17029
Zinc finger protein with KRAB and SCAN domains 4 (ZKSCAN4) Krueppel C2H2-type zinc-finger protein family Q969J2
Other
Click To Hide/Show 3 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Kelch-like ECH-associated protein 1 (KEAP1) KEAP1 family Q14145
Mitotic spindle assembly checkpoint protein MAD1 (MAD1L1) MAD1 family Q9Y6D9
SCAN domain-containing protein 1 (SCAND1) . P57086

References

1 ACR-Based Probe for the Quantitative Profiling of Histidine Reactivity in the Human Proteome. J Am Chem Soc. 2023 Mar 8;145(9):5252-5260. doi: 10.1021/jacs.2c12653. Epub 2023 Feb 27.