Details of the Target

General Information of Target

Target ID LDTP12758
Target Name Rhomboid-related protein 2 (RHBDL2)
Gene Name RHBDL2
Gene ID 54933
Synonyms
Rhomboid-related protein 2; RRP2; EC 3.4.21.105; Rhomboid-like protein 2) [Cleaved into: Rhomboid-related protein 2, N-terminal fragment; NTF; Rhomboid-related protein 2, C-terminal fragment; CTF)]
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MPDQALQQMLDRSCWVCFATDEDDRTAEWVRPCRCRGSTKWVHQACLQRWVDEKQRGNST
ARVACPQCNAEYLIVFPKLGPVVYVLDLADRLISKACPFAAAGIMVGSIYWTAVTYGAVT
VMQVVGHKEGLDVMERADPLFLLIGLPTIPVMLILGKMIRWEDYVLRLWRKYSNKLQILN
SIFPGIGCPVPRIPAEANPLADHVSATRILCGALVFPTIATIVGKLMFSSVNSNLQRTIL
GGIAFVAIKGAFKVYFKQQQYLRQAHRKILNYPEQEEA
Target Bioclass
Enzyme
Family
Peptidase S54 family
Subcellular location
Cell membrane
Function Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors. Known substrate: EFNB3.
Uniprot ID
Q9NX52
Ensemble ID
ENST00000289248.6
HGNC ID
HGNC:16083

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A2058 SNV: p.G261S .
GB1 SNV: p.A256V .
SHP77 SNV: p.R181Ter .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
STPyne
 Probe Info  		K51(0.90)  LDD0277  [1]

References

1 A Paal-Knorr agent for chemoproteomic profiling of targets of isoketals in cells. Chem Sci. 2021 Oct 15;12(43):14557-14563. doi: 10.1039/d1sc02230j. eCollection 2021 Nov 10.
Mass spectrometry data entry: PXD028270