Details of the Target

General Information of Target

Target ID LDTP12747
Target Name Thioredoxin-like protein 4B (TXNL4B)
Gene Name TXNL4B
Gene ID 54957
Synonyms
DIM2; DLP; Thioredoxin-like protein 4B; Dim1-like protein
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAAVKASTSKATRPWYSHPVYARYWQHYHQAMAWMQSHHNAYRKAVESCFNLPWYLPSAL
LPQSSYDNEAAYPQSFYDHHVAWQDYPCSSSHFRRSGQHPRYSSRIQASTKEDQALSKEE
EMETESDAEVECDLSNMEITEELRQYFAETERHREERRRQQQLDAERLDSYVNADHDLYC
NTRRSVEAPTERPGERRQAEMKRLYGDSAAKIQAMEAAVQLSFDKHCDRKQPKYWPVIPL
KF
Target Bioclass
Enzyme
Family
DIM1 family
Subcellular location
Nucleus
Function Essential role in pre-mRNA splicing. Required in cell cycle progression for S/G(2) transition.
Uniprot ID
Q9NX01
Ensemble ID
ENST00000268483.8
HGNC ID
HGNC:26041

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 4 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		N.A.  LDD0036  [1]
Lodoacetamide azide
 Probe Info  		N.A.  LDD0037  [1]
JW-RF-010
 Probe Info  		N.A.  LDD0026  [2]
NAIA_5
 Probe Info  		N.A.  LDD2223  [3]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0625  F8 Ramos C38(0.53)  LDD2187  [4]
 LDCM0573  Fragment11 Ramos C38(4.25)  LDD2190  [4]
 LDCM0586  Fragment28 Ramos C38(0.69)  LDD2198  [4]
 LDCM0566  Fragment4 Ramos C38(0.49)  LDD2184  [4]
 LDCM0569  Fragment7 Ramos C38(0.80)  LDD2186  [4]
 LDCM0022  KB02 Ramos C38(0.42)  LDD2182  [4]
 LDCM0023  KB03 Ramos C38(1.16)  LDD2183  [4]
 LDCM0024  KB05 Ramos C38(0.78)  LDD2185  [4]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 2 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Maspardin (SPG21) AB hydrolase superfamily Q9NZD8
Alpha-ketoglutarate-dependent dioxygenase alkB homolog 4 (ALKBH4) AlkB family Q9NXW9
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Class E basic helix-loop-helix protein 40 (BHLHE40) . O14503
Homeobox protein MOX-1 (MEOX1) . P50221
Proto-oncogene c-Rel (REL) . Q04864
Transcription factor 4 (TCF4) . P15884
Other
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Paraneoplastic antigen-like protein 5 (PNMA5) PNMA family Q96PV4
Aryl-hydrocarbon-interacting protein-like 1 (AIPL1) . Q9NZN9
Centrosomal AT-AC splicing factor (CENATAC) . Q86UT8
Pleckstrin homology domain-containing family F member 2 (PLEKHF2) . Q9H8W4
PRKCA-binding protein (PICK1) . Q9NRD5

References

1 Enhancing Cysteine Chemoproteomic Coverage through Systematic Assessment of Click Chemistry Product Fragmentation. Anal Chem. 2022 Mar 8;94(9):3800-3810. doi: 10.1021/acs.analchem.1c04402. Epub 2022 Feb 23.
Mass spectrometry data entry: PXD028853
2 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255
3 N-Acryloylindole-alkyne (NAIA) enables imaging and profiling new ligandable cysteines and oxidized thiols by chemoproteomics. Nat Commun. 2023 Jun 15;14(1):3564. doi: 10.1038/s41467-023-39268-w.
Mass spectrometry data entry: PXD041264
4 Site-specific quantitative cysteine profiling with data-independent acquisition-based mass spectrometry. Methods Enzymol. 2023;679:295-322. doi: 10.1016/bs.mie.2022.07.037. Epub 2022 Sep 7.
Mass spectrometry data entry: PXD027578