Details of the Target

General Information of Target

Target ID LDTP12727
Target Name PCNA-interacting partner (PARPBP)
Gene Name PARPBP
Gene ID 55010
Synonyms
C12orf48; PARI; PCNA-interacting partner; PARI; PARP-1 binding protein; PARP1-binding protein; PARPBP
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MANPKLLGMGLSEAEAIGADSARFEELLLQASKELQQAQTTRPESTQIQPQPGFCIKTNS
SEGKVFINICHSPSIPPPADVTEEELLQMLEEDQAGFRIPMSLGEPHAELDAKGQGCTAY
DVAVNSDFYRRMQNSDFLRELVITIAREGLEDKYNLQLNPEWRMMKNRPFMGSISQQNIR
SEQRPRIQELGDLYTPAPGRAESGPEKPHLNLWLEAPDLLLAEVDLPKLDGALGLSLEIG
ENRLVMGGPQQLYHLDAYIPLQINSHESKAAFHRKRKQLMVAMPLLPVPS
Target Bioclass
Other
Family
PARI family
Subcellular location
Cytoplasm
Function
Required to suppress inappropriate homologous recombination, thereby playing a central role DNA repair and in the maintenance of genomic stability. Antagonizes homologous recombination by interfering with the formation of the RAD51-DNA homologous recombination structure. Binds single-strand DNA and poly(A) homopolymers. Positively regulate the poly(ADP-ribosyl)ation activity of PARP1; however such function may be indirect.
Uniprot ID
Q9NWS1
Ensemble ID
ENST00000327680.7
HGNC ID
HGNC:26074

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
NCIH1793 Insertion: p.C299LfsTer16 .
PC9 SNV: p.Q131K .
SG231 SNV: p.G349C .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
1d-yne
 Probe Info  		N.A.  LDD0357  [1]

References

1 Tunable Amine-Reactive Electrophiles for Selective Profiling of Lysine. Angew Chem Int Ed Engl. 2022 Jan 26;61(5):e202112107. doi: 10.1002/anie.202112107. Epub 2021 Dec 16.