Details of the Target

General Information of Target

Target ID LDTP12710
Target Name RNA binding protein fox-1 homolog 1 (RBFOX1)
Gene Name RBFOX1
Gene ID 54715
Synonyms
A2BP; A2BP1; FOX1; HRNBP1; RNA binding protein fox-1 homolog 1; Ataxin-2-binding protein 1; Fox-1 homolog A; Hexaribonucleotide-binding protein 1
3D Structure
Download
2D Sequence (FASTA)
Download
3D Structure (PDB)
Download
Sequence
MMAQSKANGSHYALTAIGLGMLVLGVIMAMWNLVPGFSAAEKPTAQGSNKTEVGGGILKS
KTFSVAYVLVGAGVMLLLLSICLSIRDKRKQRQGEDLAHVQHPTGAGPHAQEEDSQEEEE
EDEEAASRYYVPSYEEVMNTNYSEARGEEQNPRLSISLPSYESLTGLDETTPTSTRADVE
ASPGNPPDRQNSKLAKRLKPLKVRRIKSEKLHLKDFRINLPDKNVPPPSIEPLTPPPQYD
EVQEKAPDTRPPD
Target Bioclass
Other
Subcellular location
Nucleus
Function
RNA-binding protein that regulates alternative splicing events by binding to 5'-UGCAUGU-3' elements. Regulates alternative splicing of tissue-specific exons and of differentially spliced exons during erythropoiesis.
Uniprot ID
Q9NWB1
Ensemble ID
ENST00000311745.9
HGNC ID
HGNC:18222

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A549 SNV: p.R369T .
COLO679 SNV: p.P396L .
EFO27 SNV: p.T80M .
MCC13 SNV: p.P293S .
MCC26 SNV: p.P125S .
MEWO SNV: p.E108G .
MFE319 Insertion: p.Y391IfsTer39 .
MIAPACA2 SNV: p.V85I .
NALM6 SNV: p.R184C .
NCIH1155 SNV: p.K200N .
SNU1 SNV: p.P33L .
TF1 SNV: p.G237R .

Probe(s) Labeling This Target

PAL-AfBPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
FFF probe13
 Probe Info  		20.00  LDD0475  [1]
FFF probe3
 Probe Info  		20.00  LDD0464  [1]

The Interaction Atlas With This Target

The Protein(s) Related To This Target

Enzyme
Click To Hide/Show 5 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Anterior gradient protein 2 homolog (AGR2) AGR family O95994
Prolyl 4-hydroxylase subunit alpha-3 (P4HA3) P4HA family Q7Z4N8
Kallikrein-6 (KLK6) Peptidase S1 family Q92876
Fibroblast growth factor receptor 3 (FGFR3) Tyr protein kinase family P22607
Ubiquitin-like protein 3 (UBL3) . O95164
Transporter and channel
Click To Hide/Show 1 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Alpha-crystallin A chain (CRYAA) Small heat shock protein (HSP20) family P02489
Transcription factor
Click To Hide/Show 4 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
AT-rich interactive domain-containing protein 5A (ARID5A) . Q03989
Class E basic helix-loop-helix protein 40 (BHLHE40) . O14503
Homeobox protein VENTX (VENTX) . O95231
Pogo transposable element with ZNF domain (POGZ) . Q7Z3K3
Other
Click To Hide/Show 17 Protein(s) Interacting with This Target
Protein name Family Uniprot ID
Ataxin-1 (ATXN1) ATXN1 family P54253
Ataxin-1-like (ATXN1L) ATXN1 family P0C7T5
Prelamin-A/C (LMNA) Intermediate filament family P02545
Proteasome inhibitor PI31 subunit (PSMF1) Proteasome inhibitor PI31 family Q92530
RNA-binding protein 47 (RBM47) RRM RBM47 family A0AV96
Toll-interacting protein (TOLLIP) Tollip family Q9H0E2
Atrophin-1 (ATN1) . P54259
DAZ-associated protein 2 (DAZAP2) . Q15038
KH domain-containing RNA-binding protein QKI (QKI) . Q96PU8
Numb-like protein (NUMBL) . Q9Y6R0
Pleckstrin homology domain-containing family A member 5 (PLEKHA5) . Q9HAU0
Protein SPMIP9 (SPMIP9) . Q96LM6
RNA binding protein fox-1 homolog 2 (RBFOX2) . O43251
RNA-binding protein with multiple splicing (RBPMS) . Q93062
RNA-binding protein with multiple splicing 2 (RBPMS2) . Q6ZRY4
Spermatid perinuclear RNA-binding protein (STRBP) . Q96SI9
Uncharacterized protein C1orf94 (C1orf94) . Q6P1W5

References

1 Ligand and Target Discovery by Fragment-Based Screening in Human Cells. Cell. 2017 Jan 26;168(3):527-541.e29. doi: 10.1016/j.cell.2016.12.029. Epub 2017 Jan 19.