Details of the Target

General Information of Target

Target ID LDTP12654
Target Name S-acyl fatty acid synthase thioesterase, medium chain (OLAH)
Gene Name OLAH
Gene ID 55301
Synonyms
THEDC1; S-acyl fatty acid synthase thioesterase, medium chain; EC 3.1.2.14; Augmented in rheumatoid arthritis 1; AURA1; Oleoyl-ACP hydrolase; Thioesterase 2; TE2; Thioesterase II; Thioesterase domain-containing protein 1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGPRPRWRDQLLFMSIIVLVIVVICLMFYALLWEAGNLTDLPNLRIGFYNFCLWNEDTS
TLQCHQFPELEALGVPRVGLGLARLGVYGSLVLTLFAPQPLLLAQCNSDERAWRLAVGFL
AVSSVLLAGGLGLFLSYVWKWVRLSLPGPGFLALGSAQALLILLLIAMAVFPLRAERAES
KLESC
Target Bioclass
Enzyme
Family
Thioesterase family
Subcellular location
Cytoplasm, cytosol
Function
Contributes to the release of free fatty acids from fatty acid synthase (FASN). Has broad substrate specificity, giving rise to a range of free fatty acids with chain lengths between 10 and 16 carbon atoms (C10 - C16).
Uniprot ID
Q9NV23
Ensemble ID
ENST00000378217.3
HGNC ID
HGNC:25625

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HEC1 SNV: p.P195S .
KNS42 SNV: p.L114V .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C243(0.90)  LDD3480  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 HCC1419 C243(1.36)  LDD2339  [1]
 LDCM0023  KB03 HCC1419 C243(1.40)  LDD2756  [1]
 LDCM0024  KB05 U2OS C243(0.90)  LDD3480  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840