Details of the Target
General Information of Target
| Target ID | LDTP12648 | |||||
|---|---|---|---|---|---|---|
| Target Name | GTPase IMAP family member 4 (GIMAP4) | |||||
| Gene Name | GIMAP4 | |||||
| Gene ID | 55303 | |||||
| Synonyms |
IAN1; IMAP4; GTPase IMAP family member 4; Immunity-associated nucleotide 1 protein; IAN-1; hIAN1; Immunity-associated protein 4 |
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| 3D Structure | ||||||
| Sequence |
MANPGGGAVCNGKLHNHKKQSNGSQSRNCTKNGIVKEAQQNGKPHFYDKLIVESFEEAPL
HVMVFTYMGYGIGTLFGYLRDFLRNWGIEKCNAAVERKEQKDFVPLYQDFENFYTRNLYM RIRDNWNRPICSAPGPLFDLMERVSDDYNWTFRFTGRVIKDVINMGSYNFLGLAAKYDES MRTIKDVLEVYGTGVASTRHEMGTLDKHKELEDLVAKFLNVEAAMVFGMGFATNSMNIPA LVGKGCLILSDELNHTSLVLGARLSGATIRIFKHNNTQSLEKLLRDAVIYGQPRTRRAWK KILILVEGVYSMEGSIVHLPQIIALKKKYKAYLYIDEAHSIGAVGPTGRGVTEFFGLDPH EVDVLMGTFTKSFGASGGYIAGRKDLVDYLRVHSHSAVYASSMSPPIAEQIIRSLKLIMG LDGTTQGLQRVQQLAKNTRYFRQRLQEMGFIIYGNENASVVPLLLYMPGKVAAFARHMLE KKIGVVVVGFPATPLAEARARFCVSAAHTREMLDTVLEALDEMGDLLQLKYSRHKKSARP ELYDETSFELED |
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| Target Bioclass |
Enzyme
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| Family |
TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily, AIG1/Toc34/Toc159-like paraseptin GTPase family, IAN subfamily
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| Subcellular location |
Cytoplasm, cytosol
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| Function | During thymocyte development, may play a role in the regulation of apoptosis. GTPase which exhibits a higher affinity for GDP than for GTP. | |||||
| Uniprot ID | ||||||
| Ensemble ID | ||||||
| HGNC ID | ||||||
Probe(s) Labeling This Target
ABPP Probe
| Probe name | Structure | Binding Site(Ratio) | Interaction ID | Ref | |
|---|---|---|---|---|---|
|
DBIA Probe Info |
 |
C220(3.08) | LDD2313 | [1] | |
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4-Iodoacetamidophenylacetylene Probe Info |
 |
C106(0.00); C187(0.00) | LDD0038 | [2] | |
|
IA-alkyne Probe Info |
 |
C106(0.00); C187(0.00); C220(0.00) | LDD0036 | [2] | |
|
Lodoacetamide azide Probe Info |
 |
C106(0.00); C187(0.00); C220(0.00) | LDD0037 | [2] | |
Competitor(s) Related to This Target
References