Details of the Target

General Information of Target

Target ID LDTP12576
Target Name Potassium voltage-gated channel subfamily D member 1 (KCND1)
Gene Name KCND1
Gene ID 3750
Synonyms
Potassium voltage-gated channel subfamily D member 1; Voltage-gated potassium channel subunit Kv4.1
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MDSDETGFEHSGLWVSVLAGLLLGACQAHPIPDSSPLLQFGGQVRQRYLYTDDAQQTEAH
LEIREDGTVGGAADQSPESLLQLKALKPGVIQILGVKTSRFLCQRPDGALYGSLHFDPEA
CSFRELLLEDGYNVYQSEAHGLPLHLPGNKSPHRDPAPRGPARFLPLPGLPPALPEPPGI
LAPQPPDVGSSDPLSMVGPSQGRSPSYAS
Target Type
Literature-reported
Target Bioclass
Transporter and channel
Family
Potassium channel family, D (Shal) (TC 1.A.1.2) subfamily, Kv4.1/KCND1 sub-subfamily
Subcellular location
Membrane
Function
Pore-forming (alpha) subunit of voltage-gated rapidly inactivating A-type potassium channels. May contribute to I(To) current in heart and I(Sa) current in neurons. Channel properties are modulated by interactions with other alpha subunits and with regulatory subunits.
TTD ID
T90905
Uniprot ID
Q9NSA2
DrugMap ID
TT4DI0J
Ensemble ID
ENST00000218176.4
HGNC ID
HGNC:6237
ChEMBL ID
CHEMBL2362996

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
A172 SNV: p.P282T .
A2780 SNV: p.F363Y .
A549 SNV: p.D78Y .
COLO679 Substitution: p.S575A .
DETROIT562 Substitution: p.S575A .
HEC1 SNV: p.V198A .
HEC1B SNV: p.V198A .
KELLY SNV: p.S631I .
KYSE30 SNV: p.L186F .
NCIH1155 SNV: p.V94M .
NUGC3 SNV: p.T192I .
OAW42 Substitution: p.S575A .
SKNSH SNV: p.S612I .
SUPT1 SNV: p.D268Y .
SW480 SNV: p.S552N .
SW620 SNV: p.S552N .
TOV21G SNV: p.R420L .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
IA-alkyne
 Probe Info  		C233(0.15); C238(0.15)  LDD2214  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0630  CCW28-3 231MFP C233(0.15); C238(0.15)  LDD2214  [1]

References

1 Covalent Ligand Screening Uncovers a RNF4 E3 Ligase Recruiter for Targeted Protein Degradation Applications. ACS Chem Biol. 2019 Nov 15;14(11):2430-2440. doi: 10.1021/acschembio.8b01083. Epub 2019 May 13.