Details of the Target

General Information of Target

Target ID LDTP12570
Target Name Carbohydrate sulfotransferase 7 (CHST7)
Gene Name CHST7
Gene ID 56548
Synonyms
Carbohydrate sulfotransferase 7; EC 2.8.2.-; EC 2.8.2.17; Chondroitin 6-sulfotransferase 2; C6ST-2; Galactose/N-acetylglucosamine/N-acetylglucosamine 6-O-sulfotransferase 5; GST-5; N-acetylglucosamine 6-O-sulfotransferase 4; GlcNAc6ST-4; Gn6st-4
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MAGHTQQPSGRGNPRPAPSPSPVPGTVPGASERVALKKEIGLLSACTIIIGNIIGSGIFI
SPKGVLEHSGSVGLALFVWVLGGGVTALGSLCYAELGVAIPKSGGDYAYVTEIFGGLAGF
LLLWSAVLIMYPTSLAVISMTFSNYVLQPVFPNCIPPTTASRVLSMACLMLLTWVNSSSV
RWATRIQDMFTGGKLLALSLIIGVGLLQIFQGHFEELRPSNAFAFWMTPSVGHLALAFLQ
GSFAFSGWNFLNYVTEEMVDARKNLPRAIFISIPLVTFVYTFTNIAYFTAMSPQELLSSN
AVAVTFGEKLLGYFSWVMPVSVALSTFGGINGYLFTYSRLCFSGAREGHLPSLLAMIHVR
HCTPIPALLVCCGATAVIMLVGDTYTLINYVSFINYLCYGVTILGLLLLRWRRPALHRPI
KVNLLIPVAYLVFWAFLLVFSFISEPMVCGVGVIIILTGVPIFFLGVFWRSKPKCVHRLT
ESMTHWGQELCFVVYPQDAPEEEENGPCPPSLLPATDKPSKPQ
Target Bioclass
Enzyme
Family
Sulfotransferase 1 family, Gal/GlcNAc/GalNAc subfamily
Subcellular location
Golgi apparatus membrane
Function
Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the transfer of sulfate to position 6 of non-reducing N-acetylglucosamine (GlcNAc) residues. Preferentially acts on mannose-linked GlcNAc. Also able to catalyze the transfer of sulfate to position 6 of the N-acetylgalactosamine (GalNAc) residue of chondroitin. Also acts on core 2 mucin-type oligosaccharide and N-acetyllactosamine oligomer with a lower efficiency. Has weak or no activity toward keratan sulfate and oligosaccharides containing the Galbeta1-4GlcNAc. Catalyzes 6-O-sulfation of beta-benzyl GlcNAc but not alpha- or beta-benzyl GalNAc.
Uniprot ID
Q9NS84
Ensemble ID
ENST00000276055.4
HGNC ID
HGNC:13817

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 2 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C202(0.92); C207(0.92)  LDD0078  [1]
W1
 Probe Info  		N.A.  LDD0236  [2]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0276  AC17 HEK-293T C202(1.24); C207(1.24)  LDD0874  [1]
 LDCM0277  AC18 HEK-293T C202(1.08); C207(1.08)  LDD0875  [1]
 LDCM0278  AC19 HEK-293T C202(1.24); C207(1.24)  LDD0876  [1]
 LDCM0280  AC20 HEK-293T C202(1.15); C207(1.15)  LDD0878  [1]
 LDCM0281  AC21 HEK-293T C202(1.51); C207(1.51)  LDD0879  [1]
 LDCM0282  AC22 HEK-293T C202(1.19); C207(1.19)  LDD0880  [1]
 LDCM0283  AC23 HEK-293T C202(1.09); C207(1.09)  LDD0881  [1]
 LDCM0284  AC24 HEK-293T C202(1.01); C207(1.01)  LDD0882  [1]
 LDCM0285  AC25 HEK-293T C202(1.06); C207(1.06)  LDD0883  [1]
 LDCM0286  AC26 HEK-293T C202(0.80); C207(0.80)  LDD0884  [1]
 LDCM0287  AC27 HEK-293T C202(0.90); C207(0.90)  LDD0885  [1]
 LDCM0288  AC28 HEK-293T C202(0.91); C207(0.91)  LDD0886  [1]
 LDCM0289  AC29 HEK-293T C202(0.94); C207(0.94)  LDD0887  [1]
 LDCM0291  AC30 HEK-293T C202(0.85); C207(0.85)  LDD0889  [1]
 LDCM0292  AC31 HEK-293T C202(0.90); C207(0.90)  LDD0890  [1]
 LDCM0293  AC32 HEK-293T C202(1.00); C207(1.00)  LDD0891  [1]
 LDCM0294  AC33 HEK-293T C202(0.99); C207(0.99)  LDD0892  [1]
 LDCM0295  AC34 HEK-293T C202(0.82); C207(0.82)  LDD0893  [1]
 LDCM0308  AC46 HEK-293T C202(0.99); C207(0.99)  LDD0906  [1]
 LDCM0309  AC47 HEK-293T C202(1.05); C207(1.05)  LDD0907  [1]
 LDCM0310  AC48 HEK-293T C202(1.03); C207(1.03)  LDD0908  [1]
 LDCM0311  AC49 HEK-293T C202(0.98); C207(0.98)  LDD0909  [1]
 LDCM0313  AC50 HEK-293T C202(1.01); C207(1.01)  LDD0911  [1]
 LDCM0314  AC51 HEK-293T C202(1.05); C207(1.05)  LDD0912  [1]
 LDCM0315  AC52 HEK-293T C202(0.98); C207(0.98)  LDD0913  [1]
 LDCM0316  AC53 HEK-293T C202(1.13); C207(1.13)  LDD0914  [1]
 LDCM0317  AC54 HEK-293T C202(1.27); C207(1.27)  LDD0915  [1]
 LDCM0318  AC55 HEK-293T C202(1.07); C207(1.07)  LDD0916  [1]
 LDCM0319  AC56 HEK-293T C202(1.06); C207(1.06)  LDD0917  [1]
 LDCM0020  ARS-1620 HCC44 C202(0.92); C207(0.92)  LDD0078  [1]
 LDCM0367  CL1 HEK-293T C202(1.05); C207(1.05)  LDD0965  [1]
 LDCM0368  CL10 HEK-293T C202(1.01); C207(1.01)  LDD0966  [1]
 LDCM0374  CL105 HEK-293T C202(1.30); C207(1.30)  LDD0972  [1]
 LDCM0375  CL106 HEK-293T C202(1.14); C207(1.14)  LDD0973  [1]
 LDCM0376  CL107 HEK-293T C202(1.34); C207(1.34)  LDD0974  [1]
 LDCM0377  CL108 HEK-293T C202(1.16); C207(1.16)  LDD0975  [1]
 LDCM0378  CL109 HEK-293T C202(1.42); C207(1.42)  LDD0976  [1]
 LDCM0379  CL11 HEK-293T C202(0.87); C207(0.87)  LDD0977  [1]
 LDCM0380  CL110 HEK-293T C202(1.38); C207(1.38)  LDD0978  [1]
 LDCM0381  CL111 HEK-293T C202(1.65); C207(1.65)  LDD0979  [1]
 LDCM0382  CL112 HEK-293T C202(0.97); C207(0.97)  LDD0980  [1]
 LDCM0383  CL113 HEK-293T C202(1.04); C207(1.04)  LDD0981  [1]
 LDCM0384  CL114 HEK-293T C202(1.26); C207(1.26)  LDD0982  [1]
 LDCM0385  CL115 HEK-293T C202(1.04); C207(1.04)  LDD0983  [1]
 LDCM0386  CL116 HEK-293T C202(0.93); C207(0.93)  LDD0984  [1]
 LDCM0390  CL12 HEK-293T C202(0.94); C207(0.94)  LDD0988  [1]
 LDCM0392  CL121 HEK-293T C202(1.17); C207(1.17)  LDD0990  [1]
 LDCM0393  CL122 HEK-293T C202(1.28); C207(1.28)  LDD0991  [1]
 LDCM0394  CL123 HEK-293T C202(1.23); C207(1.23)  LDD0992  [1]
 LDCM0395  CL124 HEK-293T C202(1.17); C207(1.17)  LDD0993  [1]
 LDCM0400  CL13 HEK-293T C202(0.89); C207(0.89)  LDD0998  [1]
 LDCM0401  CL14 HEK-293T C202(1.41); C207(1.41)  LDD0999  [1]
 LDCM0402  CL15 HEK-293T C202(1.45); C207(1.45)  LDD1000  [1]
 LDCM0407  CL2 HEK-293T C202(1.29); C207(1.29)  LDD1005  [1]
 LDCM0418  CL3 HEK-293T C202(1.03); C207(1.03)  LDD1016  [1]
 LDCM0429  CL4 HEK-293T C202(1.10); C207(1.10)  LDD1027  [1]
 LDCM0440  CL5 HEK-293T C202(0.94); C207(0.94)  LDD1038  [1]
 LDCM0451  CL6 HEK-293T C202(1.46); C207(1.46)  LDD1049  [1]
 LDCM0462  CL7 HEK-293T C202(1.41); C207(1.41)  LDD1060  [1]
 LDCM0473  CL8 HEK-293T C202(1.14); C207(0.79)  LDD1071  [1]
 LDCM0484  CL9 HEK-293T C202(1.64); C207(0.59)  LDD1082  [1]
 LDCM0022  KB02 A2058 C45(3.89)  LDD2253  [3]
 LDCM0023  KB03 A2058 C45(3.72)  LDD2670  [3]
 LDCM0024  KB05 COLO792 C45(3.16)  LDD3310  [3]

References

1 Reimagining high-throughput profiling of reactive cysteines for cell-based screening of large electrophile libraries. Nat Biotechnol. 2021 May;39(5):630-641. doi: 10.1038/s41587-020-00778-3. Epub 2021 Jan 4.
2 Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells. ACS Chem Biol. 2023 Jan 20;18(1):112-122. doi: 10.1021/acschembio.2c00740. Epub 2022 Dec 21.
3 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840