Details of the Target

General Information of Target

Target ID LDTP12562
Target Name Thrombospondin type-1 domain-containing protein 1 (THSD1)
Gene Name THSD1
Gene ID 55901
Synonyms
TMTSP; Thrombospondin type-1 domain-containing protein 1; Transmembrane molecule with thrombospondin module
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRGQGRKESLSDSRDLDGSYDQLTGHPPGPTKKALKQRFLKLLPCCGPQALPSVSETLAA
PASLRPHRPRLLDPDSVDDEFELSTVCHRPEGLEQLQEQTKFTRKELQVLYRGFKNECPS
GIVNEENFKQIYSQFFPQGDSSTYATFLFNAFDTNHDGSVSFEDFVAGLSVILRGTVDDR
LNWAFNLYDLNKDGCITKEEMLDIMKSIYDMMGKYTYPALREEAPREHVESFFQKMDRNK
DGVVTIEEFIESCQKDENIMRSMQLFDNVI
Target Bioclass
Other
Subcellular location
Endosome membrane; Membrane; Secreted
Function Is a positive regulator of nascent focal adhesion assembly, involved in the modulation of endothelial cell attachment to the extracellular matrix.
Uniprot ID
Q9NS62
Ensemble ID
ENST00000258613.5
HGNC ID
HGNC:17754

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
HCT15 SNV: p.R631M .
IM95 SNV: p.T306A .
KYSE410 SNV: p.E23K .
MFE319 SNV: p.A599V .
NCIH661 SNV: p.G54W .
OVTOKO SNV: p.D798H .
SNU5 SNV: p.Q733K .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
DBIA
 Probe Info  		C688(0.55)  LDD3380  [1]

Competitor(s) Related to This Target

Competitor ID Name Cell line Binding Site(Ratio) Interaction ID Ref
 LDCM0022  KB02 A204 C90(2.76)  LDD2252  [1]
 LDCM0023  KB03 A204 C90(4.13)  LDD2669  [1]
 LDCM0024  KB05 OV-90 C688(0.55)  LDD3380  [1]

References

1 DrugMap: A quantitative pan-cancer analysis of cysteine ligandability. Cell. 2024 May 9;187(10):2536-2556.e30. doi: 10.1016/j.cell.2024.03.027. Epub 2024 Apr 22.
Mass spectrometry data entry: PXD047840