Details of the Target

General Information of Target

Target ID LDTP12558
Target Name Double-stranded RNA-specific editase B2 (ADARB2)
Gene Name ADARB2
Gene ID 105
Synonyms
ADAR3; RED2; Double-stranded RNA-specific editase B2; EC 3.5.-.-; RNA-dependent adenosine deaminase 3; RNA-editing deaminase 2; RNA-editing enzyme 2; dsRNA adenosine deaminase B2
3D Structure
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2D Sequence (FASTA)
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3D Structure (PDB)
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Sequence
MRHSLTKLLAASGSNSPTRSESPEPAATCSLPSDLTRAAAGEEETAAAGSPGRKQQFGDE
GELEAGRGSRGGVAVRAPSPEEMEEEAIASLPGEETEDMDFLSGLELADLLDPRQPDWHL
DPGLSSPGPLSSSGGGSDSGGLWRGDDDDEAAAAEMQRFSDLLQRLLNGIGGCSSSSDSG
SAEKRRRKSPGGGGGGGSGNDNNQAATKSPRKAAAAAARLNRLKKKEYVMGLESRVRGLA
AENQELRAENRELGKRVQALQEESRYLRAVLANETGLARLLSRLSGVGLRLTTSLFRDSP
AGDHDYALPVGKQKQDLLEEDDSAGGVCLHVDKDKVSVEFCSACARKASSSLKM
Target Bioclass
Enzyme
Subcellular location
Nucleus
Function Lacks editing activity. It prevents the binding of other ADAR enzymes to targets in vitro, and decreases the efficiency of these enzymes. Capable of binding to dsRNA but also to ssRNA.
Uniprot ID
Q9NS39
Ensemble ID
ENST00000381310.7
HGNC ID
HGNC:227

Target Site Mutations in Different Cell Lines

Cell line Mutation details Probe for labeling this protein in this cell
42MGBA SNV: p.L426M .
CAL62 SNV: p.G566V .
COLO792 Deletion: p.M383PfsTer11 .
DU4475 SNV: p.A348V .
HS936T SNV: p.G86E .
HT115 SNV: p.A348V .
IGR1 SNV: p.E135K .
MCC13 SNV: p.S664P .
NCIH2291 SNV: p.A157E .
NCIH446 SNV: p.D423V .
ONS76 SNV: p.D262N .
OZ Substitution: p.P150K .
SHSY5Y SNV: p.I38L .
SKNSH SNV: p.I38L .
SKOV3 SNV: p.S16I .
TOV21G Deletion: p.F637SfsTer3
SNV: p.P150T		 .

Probe(s) Labeling This Target

ABPP Probe
Click To Hide/Show 1 Probe Related to This Target
Probe name Structure Binding Site(Ratio) Interaction ID Ref
TFBX
 Probe Info  		C294(0.00); C697(0.00)  LDD0148  [1]

References

1 Chemoproteomic Profiling by Cysteine Fluoroalkylation Reveals Myrocin G as an Inhibitor of the Nonhomologous End Joining DNA Repair Pathway. J Am Chem Soc. 2021 Dec 8;143(48):20332-20342. doi: 10.1021/jacs.1c09724. Epub 2021 Nov 24.
Mass spectrometry data entry: PXD029255